{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T15:30:44Z","timestamp":1787671844112,"version":"build-2736575974"},"reference-count":16,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp;amp; Cancer"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Juvenile xanthogranuloma (JXG) of the central nervous system (CNS) is a rare non\u2010Langerhans cell histiocytosis\n                    <jats:italic>. CSF1R<\/jats:italic>\n                    mutations have been reported for peripheral JXG, but not in CNS JXG. A 3\u2010month\u2010old male presented with fever, lymphadenopathy, and macrocephaly with bulging fontanelles. Imaging demonstrated multiple dural\u2010based masses causing obstructive hydrocephalus. The patient underwent right frontal endoscopic third ventriculostomy, choroid plexus cauterization, and craniotomy for resection and tissue diagnosis. Pathology was consistent with JXG, and NGS identified a somatic\n                    <jats:italic>CSF1R<\/jats:italic>\n                    mutation. Liquid imatinib monotherapy led to resolution of lesions and continued treatment response after 3\u00a0years without adverse events or drug interruptions.\n                  <\/jats:p>","DOI":"10.1002\/1545-5017.70585","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T09:50:36Z","timestamp":1786960236000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Infantile Central Nervous System Juvenile Xanthogranuloma With Somatic\n                    <i>CSF1R<\/i>\n                    Mutation Responsive to Imatinib Monotherapy"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2033-314X","authenticated-orcid":false,"given":"Sima","family":"Vazquez","sequence":"first","affiliation":[{"name":"Department of Neurosurgery University of Miami Miller School of Medicine\/Jackson Health System\u2010Holtz Children's Hospital  Miami Florida 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