{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:35:18Z","timestamp":1787758518482,"version":"build-2784847793"},"reference-count":16,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Rhabdomyosarcoma is the most common childhood soft tissue sarcoma. We report a 4\u2010year\u2010old male child with Li\u2010Fraumeni syndrome and germline tumor protein 53 gene (TP53) mutation presenting with a supraclavicular mass. Pathology revealed embryonal rhabdomyosarcoma with anaplastic features and positive margins. Although standard management includes radiotherapy for positive margins, Li\u2010Fraumeni syndrome markedly elevates radiation\u2010induced secondary malignancy risk. Therefore, re\u2010resection was recommended to achieve clear margins and limit radiation exposure. Because the margin location was uncertain, the fluorescent agent pegulicianine (LUMISIGHT) was administered for intraoperative tumor identification. This represents the first documented pediatric use of this agent. The patient tolerated pegulicianine and intraoperative imaging without complications.<\/jats:p>","DOI":"10.1002\/1545-5017.70587","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T09:36:44Z","timestamp":1784799404000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["First Pediatric Use of Pegulicianine for Fluorescence\u2010Guided Surgery in Li\u2010Fraumeni\u2010Associated Rhabdomyosarcoma"],"prefix":"10.1002","volume":"73","author":[{"given":"Amirbahador Golchin Sani","family":"Masouleh","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Jin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of Pittsburgh Medical Center  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tulio","family":"Valdez","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasu","family":"Divi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki Wan Roy","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Miranda","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4983-3068","authenticated-orcid":false,"given":"Kara","family":"Meister","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.30556"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29351"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aad0293"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/EVIDoa2200333"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28507"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.30437"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers18010149"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.28772"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3171\/2025.5.PEDS24630"},{"key":"e_1_2_7_11_1","unstructured":"PDQ Pediatric Treatment Editorial Board \u201cChildhood Rhabdomyosarcoma Treatment (PDQ\u00ae): Health Professional Version \u201d inPDQ Cancer Information Summaries (National Cancer Institute 2002) accessed November 4 2025 http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK65802\/."},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13143567"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.3427"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2024.3683"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1748\u2010717X\u20105\u2010104"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2022.1075"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9101388"}],"container-title":["Pediatric Blood &amp; 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