{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T15:31:24Z","timestamp":1793287884629,"version":"4.5.0"},"reference-count":12,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012659","name":"Foundation for Innovative Research Groups of the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82000151"],"award-info":[{"award-number":["82000151"]}],"id":[{"id":"10.13039\/501100012659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp;amp; Cancer"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    We measured dasatinib concentrations in paired plasma and cerebrospinal fluid (CSF) samples from children with Philadelphia chromosome\u2013positive acute lymphoblastic leukemia (Ph+ ALL). Blood samples were collected from children at 0\u00a0h (pre\u2010dasatinib) and 2\u00a0h post\u2010dasatinib, along with CSF. After validating a liquid chromatography\u2010tandem mass spectrometry (LC\u2010MS\/MS) assay for dasatinib in both matrices, we quantified drug concentrations in plasma and CSF and expressed blood\u2013brain barrier penetration as the plasma\u2010to\u2010CSF concentration ratio. Twenty children with Ph\n                    <jats:sup>+<\/jats:sup>\n                    ALL, who received oral dasatinib (60\u201380\u00a0mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    \u00b7day), were included in this study. The median age was 10.8 (5\u201316) years, with 13 males (65%) and 7 females (35%). In plasma, the mean dasatinib concentrations were 1.3 \u00b1 0.7\u00a0ng\/mL at 0 h and 101.6 \u00b1 42.1\u00a0ng\/mL at 2 h. In CSF, the mean dasatinib concentration was 0.5 \u00b1 0.2\u00a0ng\/mL at 2 h. The median paired plasma\/CSF concentration ratio was 225:1 (98:1\u2013406:1). In conclusion, despite therapeutic systemic levels, dasatinib penetrates poorly into CSF in children with Ph\n                    <jats:sup>+<\/jats:sup>\n                    ALL.\n                  <\/jats:p>","DOI":"10.1002\/1545-5017.70588","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T11:04:33Z","timestamp":1786446273000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Low Dasatinib Penetration of the Blood\u2013Brain Barrier in Children With Philadelphia Chromosome\u2013Positive Acute Lymphoblastic Leukemia: Evidence From LC\u2010MS\/MS Analysis"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0485-2422","authenticated-orcid":false,"given":"Fangyuan","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Pediatrics Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingming","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aidong","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueping","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaizhi","family":"Lu","sequence":"additional","affiliation":[{"name":"Mass Spectrometry Research Institute, Beijing Gobroad Healthcare Group  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,11]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000547026"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-019-0205-x"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-022-01032-5"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm-20-3140"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.14712\/23362936.2019.10"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-025-03130-7"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-023-02018-5"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1146108"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2021.05.009"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-021-00529-6"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-020-09848-z"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-15-0093"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1545-5017.70588","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/1545-5017.70588","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1545-5017.70588","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T14:33:05Z","timestamp":1793284385000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/1545-5017.70588"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,11]]},"references-count":12,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/1545-5017.70588"],"URL":"https:\/\/doi.org\/10.1002\/1545-5017.70588","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,11]]},"assertion":[{"value":"2026-04-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70588"}}