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Studies in acute lymphoblastic leukemia (ALL) suggest health\u2010related quality of life (HRQOL) may improve by 1\u2010month post\u2010infusion. However, patient\u2010reported outcomes remain insufficiently characterized, particularly across the broader pediatric CAR T\u2010cell population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Procedure<\/jats:title>\n                    <jats:p>English\u2010 or Spanish\u2010speaking patients (ages 8\u201325 years) receiving CAR T\u2010cell therapy for any malignancy were recruited from three US pediatric cancer centers. Patient\u2010reported HRQOL (PedsQL) and symptom burden (Memorial Symptom Assessment Scale [MSAS]) were assessed serially through 12 months post\u2010infusion, emphasizing the first month. Linear mixed models characterized score trajectories and examined associations between symptom burden and HRQOL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifty\u2010nine patients completed baseline HRQOL assessments; 41% were treated for ALL. Median age was 17 years and 46% identified as female. Participants completed a median of six assessments, with nearly 75% obtained within the first month. Scores were worst at baseline (mean [SD]: PedsQL Generic: 64.9 [18.4], PedsQL Cancer: 70.0 [16.2], MSAS: 24.4 [19.4]) and improved post\u2010infusion. The greatest gains from baseline to 4 weeks were seen in physical functioning (mean +\u00a08) and worry (mean +\u00a020). Across all timepoints, the most burdensome symptoms were fatigue, worry, pain, nervousness, and anorexia. Symptom burden demonstrated a strong negative correlation with HRQOL (\n                      <jats:italic>r<\/jats:italic>\n                      = \u2013\u00a00.81,\n                      <jats:italic>p<\/jats:italic>\n                      &lt;\u00a0 0.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Pediatric patients undergoing CAR T\u2010cell therapy experience generally favorable HRQOL trajectories and modest, time\u2010limited symptom burden. Serial patient\u2010reported outcome collection is feasible in this population and provides actionable insight to guide supportive care delivery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1545-5017.70589","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T12:49:56Z","timestamp":1785502196000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Health\u2010Related Quality of Life and Symptom Burden in Pediatric Patients Receiving CAR T\u2010Cell Therapy: A Prospective, Longitudinal Patient\u2010Reported Outcomes Study"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8000-0179","authenticated-orcid":false,"given":"Angela","family":"Steineck","sequence":"first","affiliation":[{"name":"MACC Fund Center for Cancer and Blood Disorders Department of Pediatrics Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Bioinformatics and Quantitative Child Health Department of Pediatrics Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy Y.","family":"Pan","sequence":"additional","affiliation":[{"name":"Division of Bioinformatics and Quantitative Child Health Department of Pediatrics Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8998-4530","authenticated-orcid":false,"given":"Mallory R.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Cancer and Blood Disorders Center Department of Pediatrics University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara K.","family":"Silbert","sequence":"additional","affiliation":[{"name":"Pediatric Oncology Branch National Cancer Institute National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haneen","family":"Shalabi","sequence":"additional","affiliation":[{"name":"Novartis  East Hanover New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liam","family":"Comiskey","sequence":"additional","affiliation":[{"name":"Department of Psychosocial Oncology and Palliative Care Dana\u2010Farber Cancer Institute  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer M.","family":"Knight","sequence":"additional","affiliation":[{"name":"Departments of Psychiatry Medicine, and Microbiology and Immunology Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9573-8870","authenticated-orcid":false,"given":"Lori","family":"Wiener","sequence":"additional","affiliation":[{"name":"Pediatric Oncology Branch National Cancer Institute National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deena","family":"Levine","sequence":"additional","affiliation":[{"name":"Division of Quality of Life and Palliative Care Department of Oncology St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,31]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/OP.23.00159"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887\u2010022\u201003635\u20101"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.00642"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(19)30493\u20100"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159\u20108290.CD\u201016\u20100040"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021011898"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010018\u20100918\u2010x"},{"issue":"10","key":"e_1_2_11_9_1","first-page":"664","article-title":"Tisagenlecleucel in Pediatric Patients With Acute Lymphoblastic Leukemia","volume":"16","author":"Maude S. 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