{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:17:30Z","timestamp":1787761050326,"version":"build-2784847793"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T00:00:00Z","timestamp":1784937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T00:00:00Z","timestamp":1784937600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Myoepithelial carcinoma (MEC) in pediatric patients is a rare and aggressive malignancy characterized by heterogeneous morphology and variable molecular features. The optimal role of chemotherapy remains unclear. We conducted a systematic review according to PRISMA 2020 guidelines to evaluate chemotherapy in pediatric and young\u2010adult patients with extra\u2010salivary MEC. Twenty\u2010one studies including 40 patients were analyzed. Chemotherapy response was evaluable in 19 patients, with partial responses in 57.9%, stable disease in 15.8%, and progressive disease in 26.3%; no complete responses were observed with chemotherapy alone. Comparable activity was found between TREP\u2010based (ICpE) and sarcoma\u2010like regimens, with no evidence of superiority of one regimen over the other, but supporting ifosfamide\u2010based combinations as a therapeutic backbone. Radiotherapy and complete surgical resection were associated with improved local control. At a median follow\u2010up of 21 months, 35% of patients were alive with no evidence of disease, while 37.5% had died of disease. Patients with\n                    <jats:italic>EWSR1<\/jats:italic>\n                    rearrangements showed relatively favorable outcomes. Overall, chemotherapy demonstrates limited efficacy, and a multimodal approach remains essential. These findings highlight the need for international guidelines within the EXPeRT group to standardize management and improve outcomes.\n                  <\/jats:p>","DOI":"10.1002\/1545-5017.70595","type":"journal-article","created":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T09:14:37Z","timestamp":1784970877000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Role of Chemotherapy in Pediatric Myoepithelial Carcinoma: A Systematic Review of the Literature"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2273-1492","authenticated-orcid":false,"given":"Marco","family":"Salvi","sequence":"first","affiliation":[{"name":"Department of Pediatrics University of Milano\u2010Bicocca  Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1680-0240","authenticated-orcid":false,"given":"Maria 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