{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T15:30:59Z","timestamp":1787671859529,"version":"build-2736575974"},"reference-count":14,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp;amp; Cancer"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Nephrogenic rests (NRs) and nephroblastomatosis (NBM) are precursor lesions for development of Wilms tumor (WT). Their association with the risk of relapse has not been properly assessed, partly due to misunderstanding of their diagnostic criteria and terminology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>Retrospective data analysis of patients with WT with and without associated NRs\/NBM diagnosed and treated according to the International Society of Paediatric Oncology\u2010WT\u20102001 protocol in the United Kingdom (UK) Children's Cancer and Leukaemia Group (UK\u2010CCLG) and Gesellschaft f\u00fcr P\u00e4diatrische Onkologie und H\u00e4matologie (GPOH) groups' participation in the WT trials and studies (2001\u20132022).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There were 1465 (59.5%) patients with no NRs (Group A), and 996 (40.7%) with NRs (Group B); the latter included 678 (68.1%) patients with perilobar NRs (PLNRs) (Group C), 250 (25.1%) with intralobar NRs (ILNRs) (Group D), and 68 (6.8%) with combined PL\/ILNRs (Group E). There was no significant difference in relapse\u2010free survival (RFS) and overall survival (OS) between Groups A\u2013D. Univariate Cox regression analyses showed no significant prognostic impact on RFS or OS of age at diagnosis (only RFS), local stage, metastatic disease, and histology and no impact on NRs. Multivariate Cox regression analysis, including age, sex, histology, local stage, metastatic disease, and NRs, showed no significant effect on either RFS or OS for Group A versus B, Group A versus C, or Group A versus D.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The study showed that the presence of NRs\/NBM in unilateral WT is of no significance for RFS and OS, and therefore, these patients should not be treated or followed up differently from patients with WT without NRs\/NBM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1545-5017.70598","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T12:47:45Z","timestamp":1785502065000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nephrogenic Rests\/Nephroblastomatosis in Patients With Unilateral Wilms Tumor Are Not Associated With an Increased Risk of Relapse: An Analysis of Patients Treated on the SIOP\u2010WT\u20102001 Protocol in the SIOP\u2010UK\u2010CCLG and SIOP\u2010GPOH Studies (2001\u20132022)"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0726-6939","authenticated-orcid":false,"given":"Gordan M.","family":"Vujani\u0107","sequence":"first","affiliation":[{"name":"Department of Pathology Sidra Medicine  Doha Qatar"},{"name":"Weill Cornell Medicine \u2010 Qatar  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1967-8343","authenticated-orcid":false,"given":"Rhoikos","family":"Furtw\u00e4ngler","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology and Oncology Department of Pediatrics Inselspital University Hospital University of Bern  Bern Switzerland"},{"name":"Department of Paediatric Haematology and Oncology Saarland University Hospital  Homburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3891-5778","authenticated-orcid":false,"given":"Tanzina","family":"Chowdhury","sequence":"additional","affiliation":[{"name":"Department of Haematology and Oncology Great Ormond Street Hospital for Children NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4138-4536","authenticated-orcid":false,"given":"Christian","family":"Vokuhl","sequence":"additional","affiliation":[{"name":"Department of Pathology, Division of Paidopathology, University Hospital Bonn University of Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4505-5519","authenticated-orcid":false,"given":"Jenny","family":"Wegert","sequence":"additional","affiliation":[{"name":"Developmental Biochemistry, Theodor\u2010Boveri\u2010Institute\/Biocenter Julius\u2010Maximilians\u2010University Wurzburg  Wurzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2248-323X","authenticated-orcid":false,"given":"Norbert","family":"Graf","sequence":"additional","affiliation":[{"name":"Department of Paediatric Haematology and Oncology Saarland University Hospital  Homburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,31]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13133142"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0959\u20108049(00)00409\u20103"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-023-03493-5"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.30162"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.19.22301"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/15513819009067094"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20891"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26547"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.2950210303"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00125480-200109000-00005"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1590\/s1677-5538.ibju.2020.0694"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073\u2010025\u201001482\u20100"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20386"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1371840"}],"container-title":["Pediatric Blood &amp; 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