{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:17:46Z","timestamp":1787761066080,"version":"build-2784847793"},"reference-count":16,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Blinatumomab, a CD19xCD3 bispecific T\u2010cell engager, has become standard therapy for children with de novo B\u2010cell acute lymphoblastic leukemia (B\u2010ALL). This retrospective review describes the experience of blinatumomab administration in pediatric patients. At our institution, 31 children with B\u2010ALL received continuous intravenous (IV) blinatumomab from January 1, 2018, to December 31, 2024. Logistical issues requiring clinical intervention occurred in 16 (51.6%) patients, with 57.8% of these issues resulting in hospitalization. After receiving blinatumomab, 26 patients (83.9%) required intravenous immunoglobulin (IVIG). These results support investigations into alternative methods of blinatumomab delivery and the impact of blinatumomab on immune function in pediatric patients with B\u2010ALL.<\/jats:p>","DOI":"10.1002\/1545-5017.70599","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T07:09:08Z","timestamp":1785481748000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Administering Blinatumomab via Continuous Intravenous Infusion in Pediatric Patients\u2014A Single\u2010Institution Retrospective Review"],"prefix":"10.1002","volume":"73","author":[{"given":"Julia M.","family":"Hurley","sequence":"first","affiliation":[{"name":"Michigan State University College of Human Medicine  Grand Rapids Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryleigh","family":"Krueger","sequence":"additional","affiliation":[{"name":"Pediatric Hematology\/Oncology\/BMT Division Helen DeVos Children's Hospital at Corewell Health  Grand Rapids Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3157-2169","authenticated-orcid":false,"given":"Kellie","family":"Joyce","sequence":"additional","affiliation":[{"name":"Pediatric Hematology\/Oncology\/BMT Division Helen DeVos Children's Hospital at Corewell Health  Grand Rapids Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6106-8823","authenticated-orcid":false,"given":"James","family":"Stanley","sequence":"additional","affiliation":[{"name":"Pediatric Hematology\/Oncology\/BMT Division Helen DeVos Children's Hospital at Corewell Health  Grand Rapids Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Waskerwitz\u2010Freyer","sequence":"additional","affiliation":[{"name":"Pediatric Hematology\/Oncology\/BMT Division Helen DeVos Children's Hospital at Corewell Health  Grand Rapids Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marielle","family":"Klunder","sequence":"additional","affiliation":[{"name":"Pediatric Hematology\/Oncology\/BMT Division Helen DeVos Children's Hospital at Corewell Health  Grand Rapids Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5386-3254","authenticated-orcid":false,"given":"David J.","family":"Hoogstra","sequence":"additional","affiliation":[{"name":"Michigan State University College of Human Medicine  Grand Rapids Michigan USA"},{"name":"Pediatric Hematology\/Oncology\/BMT Division Helen DeVos Children's Hospital at Corewell Health  Grand Rapids Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,31]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21219"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmra1400972"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2411680"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1078155215618770"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.31913"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/NCC.0000000000001309"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/27527530241267303"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/EDBK\u201025\u2010472778"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2019.103208"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.67.3301"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.0987"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/1078155220979047"},{"key":"e_1_2_10_15_1","unstructured":"\u201cBLINCTYO (Blinatumomab); 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