{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:00:19Z","timestamp":1790172019762,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp;amp; Cancer"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Neurological manifestations in children with hemoglobin SC (HbSC) disease remain insufficiently characterized, particularly regarding acute events. The aim of this study was to describe the spectrum and frequency of acute neurological events in a multicenter cohort of children with HbSC disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective descriptive multicenter study including children with HbSC disease aged 0\u201318\u00a0years who presented with at least one acute neurological event between January 1, 2010, and August 31, 2023, in \u00cele\u2010de\u2010France, Martinique, and Guadeloupe.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty\u2010five patients from 10 centers were included. A total of 34 acute neurological events were recorded. Neuro\u2010ENT (ear, nose, throat) manifestations were the most frequent (41%), including vestibular syndromes and sudden hearing loss, followed by central neurological deficits or altered consciousness (18%), seizures (18%), acute headaches (18%), and peripheral neuropathies (6%). Neuro\u2010ENT manifestations showed recurrence in some patients. Cerebrovascular events occurred across all age groups and were observed in patients with a history of vaso\u2010occlusive crises.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Acute neurological events may occur in children with HbSC disease and show a heterogeneous clinical spectrum. Further studies are needed to better characterize their determinants and clinical significance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Trial Registration<\/jats:title>\n                    <jats:p>Not applicable.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1545-5017.70605","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T12:50:36Z","timestamp":1787230236000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Acute Neurological Events in Children With Hemoglobin SC Disease: A Multicenter Retrospective Study"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-6092-3687","authenticated-orcid":false,"given":"C\u00e9lia","family":"Paulmin","sequence":"first","affiliation":[{"name":"Le Kremlin Bic\u00eatre Reference Center for Rare Constitutional Disorders of the Red Blood Cell and Erythropoiesis (MCGRE) Bic\u00eatre Hospital  Le Kremlin\u2010Bic\u00eatre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7087-7199","authenticated-orcid":false,"given":"B\u00e9reng\u00e8re","family":"Koehl","sequence":"additional","affiliation":[{"name":"Sickle Cell Disease Center Hematology Unit Robert Debr\u00e9 Hospital Universit\u00e9 Paris Cit\u00e9 Inserm BIGR\u2010team Bahsic  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Maudoux","sequence":"additional","affiliation":[{"name":"Pediatric ENT and Head and Neck Surgery Robert Debr\u00e9 Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanine","family":"Mansour","sequence":"additional","affiliation":[{"name":"Fort\u2010de\u2010France Reference Center MCGRE University Hospital of Martinique  Martinique 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