{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T15:30:55Z","timestamp":1787671855587,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp;amp; Cancer"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Rhabdomyosarcoma represents the most common paediatric soft tissue sarcoma, with 40% occurring in the head and neck region. Given that survival rates now reach 80%, minimising late adverse effects, particularly dental developmental complications, has become a priority. The aim of this paper was to identify the scope, severity and range of such late dental effects following treatment for head and neck sarcoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We systematically investigated late dental adverse events using orthopantomograms in rhabdomyosarcoma survivors treated between 1990 and 2014. Orthopantomograms were evaluated using a validated scoring system (DENTALE) that evaluates skeletal deformations, tooth presence, tooth wear, crown shape, eruption, root\u2010crown ratio and root shape.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 103 survivors (median age at diagnosis 5.4 years, 42.7% female), 92.2% exhibited dental adverse effects. Missing molars occurred in 45.6% of survivors. Root abnormalities were present in 72.8% of survivors, crown\u2010to\u2010root ratio abnormalities in 56.3% and eruption disturbances in 45.6%. Age at diagnosis was inversely correlated with total adverse effect score (\n                      <jats:italic>\n                        r\n                        <jats:sub>s<\/jats:sub>\n                      <\/jats:italic>\n                      \u00a0 = \u22120.389,\u00a0\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt; 0.001). Survivors diagnosed before age 6 had significantly higher total dental adverse effect scores (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.008), showing more effects of crowns (\n                      <jats:italic>p =<\/jats:italic>\n                      0.016), crown\u2010root ratio (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.020), tooth eruption (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.005) and roots (\n                      <jats:italic>p =<\/jats:italic>\n                      0.006).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study demonstrates that rhabdomyosarcoma survivors are at substantial risk for a variety of dental developmental issues when treated at a younger age. Consequently, routine dental screening during follow\u2010up is essential, with specialised dental and orthodontic care provided when clinically indicated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1545-5017.70609","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T12:25:22Z","timestamp":1786364722000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Radiological Late Dental Adverse Effects Following Treatment for Paediatric Head and Neck Rhabdomyosarcoma: Results of a Transatlantic Multicentre Cohort Study"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-2593-6393","authenticated-orcid":false,"given":"Koen B.","family":"Krommenhoek","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Academic Centre for Dentistry Amsterdam (ACTA)  Amsterdam the Netherlands"},{"name":"Department of Oral and Maxillofacial Surgery Amsterdam UMC University of Amsterdam  Amsterdam the Netherlands"},{"name":"Princess M\u00e1xima Centre For Paediatric Oncology  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marinka L. F.","family":"Hol","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Centre For Paediatric Oncology  Utrecht the Netherlands"},{"name":"Department of Otolaryngology and Head and Neck Cancer Utrecht University  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5765-9055","authenticated-orcid":false,"given":"Poyan","family":"Maghsoudi","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Academic Centre for Dentistry Amsterdam (ACTA)  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J. T.","family":"Leung","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Academic Centre for Dentistry Amsterdam (ACTA)  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8838-981X","authenticated-orcid":false,"given":"Reineke A.","family":"Schoot","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Centre For Paediatric Oncology  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willem M. M.","family":"Fennis","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Prosthodontics and Special Dental Care University Medical Centre Utrecht  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5765-1873","authenticated-orcid":false,"given":"Daniel J.","family":"Indelicato","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Florida College of Medicine  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Slater","sequence":"additional","affiliation":[{"name":"Department of Paediatric Oncology Great Ormond Street Hospital for Children NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Kolb","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, Department of Surgery University of California San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9985-6615","authenticated-orcid":false,"given":"Reinier C.","family":"Hoogeveen","sequence":"additional","affiliation":[{"name":"Department of Oral Radiology and Digital Dentistry, Academic Centre for Dentistry Amsterdam (ACTA) University of Amsterdam &amp; Vrije Universiteit Amsterdam  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes H. M.","family":"Merks","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Centre For Paediatric Oncology  Utrecht the Netherlands"},{"name":"Division of Imaging and Oncology University Medical Centre Utrecht, Utrecht University  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfred G.","family":"Becking","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Academic Centre for Dentistry Amsterdam (ACTA)  Amsterdam the Netherlands"},{"name":"Department of Oral and Maxillofacial Surgery Amsterdam UMC University of Amsterdam  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.40.3287"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2021.04.007"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.27994"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2014.11.009"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24374"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2012.11.041"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2015.02.010"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2021.04.023"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(06)70658\u20101"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/08880018.2013.763391"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1054\/ctrv.2002.0254"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2018.12.012"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2026.1797184"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.32004"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010022\u201008266\u20101"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360\u20103016(00)00799\u20109"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/08880010500198848"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096\u2010911X(199801)30:1<22::AID\u2010MPO8>3.0.CO;2\u20102"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-008-0567-1"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2014(06)11"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24842"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010014\u20102260\u2010x"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.2950250209"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.25840"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/dj12010017"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1597\/03\u2010097.3.1"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.39.3611"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1259\/dmfr.20190275"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1080\/08880018.2016.1219797"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2014.08.033"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.1673"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.06.1942"}],"container-title":["Pediatric Blood &amp; 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