{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:59:58Z","timestamp":1790171998968,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp;amp; Cancer"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Arterial hypertension (AH) is a common clinical finding at the time of Wilms tumor (WT) diagnosis, is often difficult to manage, and is potentially related to acute complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed 147 patients with newly diagnosed WT treated between January 2010 and December 2023 at two high\u2010volume Italian pediatric oncology centers. Demographic, clinical, treatment, and tumor characteristics were evaluated in relation to the presence of AH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At WT diagnosis, 75\/147 (51%) of patients were hypertensive. Large tumor volume (continuous variable,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.011), advanced tumor stage (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.012), bilateral disease (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.015), and renal vascular involvement (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.004) were significantly associated with AH. Calcium channel blockers were the most frequently used antihypertensive agents, followed by angiotensin converting enzyme inhibitors. Six out of 75 (8%) of patients suffered from secondary complications related to AH.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We confirmed the high prevalence of AH at WT diagnosis and identified tumor\u2010related factors associated with an increased risk of developing AH. The key elements for the adequate management of these patients include the use of appropriate antihypertensive therapy and proper routine blood pressure screening for all patients with a new WT diagnosis.<\/jats:p>\n                    <jats:p>In the absence of standardized treatment guidelines, we propose recommendations developed through collaboration among pediatric oncologists, cardiologists, and nephrologists.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>EudraCT number 2016\u2010004180\u201039<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1545-5017.70617","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T09:54:27Z","timestamp":1787046867000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hypertension in Wilms Tumor at Diagnosis: Proposed Treatment Recommendations Starting From a Bi\u2010Institutional Retrospective Observational Study"],"prefix":"10.1002","volume":"73","author":[{"given":"Alessandra","family":"Bondanese","sequence":"first","affiliation":[{"name":"Postgraduate School of Pediatrics University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8337-2752","authenticated-orcid":false,"given":"Giovanna","family":"Gattuso","sequence":"additional","affiliation":[{"name":"Pediatric Oncology Department Fondazione IRCCS Istituto Nazionale dei Tumori  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittoria","family":"Hassan","sequence":"additional","affiliation":[{"name":"Pediatric Oncology Department Fondazione IRCCS Istituto Nazionale dei Tumori  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta Giorgia","family":"Podda","sequence":"additional","affiliation":[{"name":"Pediatric 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Children's Hospital  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5861-9307","authenticated-orcid":false,"given":"Francesca","family":"Torchio","sequence":"additional","affiliation":[{"name":"Pediatric Onco\u2010Hematology, Stem Cell Transplantation and Cellular Therapy Division Regina Margherita Children's Hospital  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7077-9203","authenticated-orcid":false,"given":"Lucia","family":"Mauri","sequence":"additional","affiliation":[{"name":"Pediatric Cardiology ASST Grande Ospedale Metropolitano Niguarda  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7759-0550","authenticated-orcid":false,"given":"Sara","family":"Pizzamiglio","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Data Science, Bioinformatics and Biostatistics Unit Fondazione IRCCS Istituto Nazionale dei Tumori  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Verderio","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Data Science, Bioinformatics and Biostatistics Unit Fondazione IRCCS Istituto Nazionale dei Tumori  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5704-3867","authenticated-orcid":false,"given":"Licia","family":"Peruzzi","sequence":"additional","affiliation":[{"name":"Pediatric Nephrology Unit Regina Margherita Children's Hospital, University of Turin, AOU Citt\u00e0 della Salute e della Scienza di Torino  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7350-4475","authenticated-orcid":false,"given":"Giovanni","family":"Montini","sequence":"additional","affiliation":[{"name":"Pediatric Nephrology, Dialysis and Transplantation Unit 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