{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T15:31:24Z","timestamp":1793287884563,"version":"4.5.0"},"reference-count":18,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp;amp; Cancer"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The WHO Global Initiative for Childhood Cancer (GICC) targets a global survival rate of 60% for childhood cancer, focusing initially on six common and curable cancers. This study assessed the risk of treatment abandonment (TxA) and the impact on survival of five of these cancers in sub\u2010Saharan Africa in preparation for a cash transfer intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This multi\u2010centre, prospective, observational cohort study included newly diagnosed children (&lt;16 years) with Burkitt lymphoma (BL), acute lymphoblastic leukaemia (ALL), Wilms tumour (WT), retinoblastoma (RB) or Hodgkin disease (HD), enrolled between January 2022 and April 2024 from hospitals in Ethiopia (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a02) and Uganda. Event\u2010free survival (EFS) was estimated using Kaplan\u2013Meier methods, and the cumulative incidence of TxA was estimated using competing risks methods.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 370 patients enrolled (median age 6 years, 62% boys), ALL was the most common diagnosis (30%, 112\/370). Median follow\u2010up was 26 months (range 6\u201335 months). The overall risk of treatment abandonment was 43%, ranging from 20% in Mbarara, Uganda to 54% in Gondar, Ethiopia. It was highest in patients with WT (48%) and RB (49%). Overall, 2\u2010year EFS was 28% (confidence interval [CI] 24%\u201334%) with TxA as an event and 59% (53%\u201366%) when TxA cases were censored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The overall risk of treatment abandonment is high, 43%, in this baseline \u2018Zero Abandonment\u2019 study in participating hospitals in Ethiopia and Uganda. Treatment abandonment significantly affects survival, currently 28%, and potentially to increase to 59% if treatment abandonment was completely prevented.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1545-5017.70621","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T11:20:16Z","timestamp":1786447216000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Baseline Risk of Treatment Abandonment and Survival of Children With Common and Curable Cancers in the Zero Abandonment Cash Transfer Programme\u2014A Multi\u2010Centre Prospective CANCaRe Africa Study"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1679-4975","authenticated-orcid":false,"given":"Yalew Melkamu","family":"Molla","sequence":"first","affiliation":[{"name":"Department of Pediatrics and Child Health Unit of Pediatric Hematology Oncology University of Gondar College of Medicine and Health Science  Gondar Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esubalew","family":"Mezgebu","sequence":"additional","affiliation":[{"name":"Pediatrics and Child Health Jimma University  Jimma Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barnabas","family":"Atwiine","sequence":"additional","affiliation":[{"name":"Mbarara University of Science and Technology  Mbarara Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Mdoka","sequence":"additional","affiliation":[{"name":"CANCaRe Africa (The Collaborative African Network for Childhood Cancer Care and Research)  Blantyre Malawi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4079-0524","authenticated-orcid":false,"given":"Mulugeta","family":"Wassie","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Child Health Unit of Pediatric Hematology Oncology University of Gondar College of Medicine and Health Science  Gondar Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mushabe","family":"Branchard","sequence":"additional","affiliation":[{"name":"Mbarara University of Science and Technology  Mbarara Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mulugeta Ayalew","family":"Yimer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Child Health Unit of Pediatric Hematology Oncology University of Gondar College of Medicine and Health Science  Gondar Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Zobeck","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7574-3237","authenticated-orcid":false,"given":"Diriba","family":"Fufa","sequence":"additional","affiliation":[{"name":"Pediatrics and Child Health Jimma University  Jimma Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4309-4994","authenticated-orcid":false,"given":"Trijn","family":"Israels","sequence":"additional","affiliation":[{"name":"CANCaRe Africa (The Collaborative African Network for Childhood Cancer Care and Research)  Blantyre Malawi"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30909-4"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(23)00173-0"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30761-7"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(21)00720-8"},{"key":"e_1_2_11_6_1","volume-title":"WHO Global Initiative for Childhood Cancer","author":"WH 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