{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T15:31:03Z","timestamp":1787671863494,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp;amp; Cancer"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Purpose<\/jats:title>\n                    <jats:p>Total body irradiation (TBI) is a standard component of conditioning regimens for pediatric patients with acute lymphoblastic leukemia (ALL) undergoing hematopoietic stem cell transplantation (HSCT). Volumetric modulated arc therapy (VMAT) has emerged as a promising technique to improve dose conformity and organ\u2010at\u2010risk (OAR) sparing. This study evaluates the feasibility, dosimetric performance, and acute toxicity of a VMAT\u2010based TBI (VMAT\u2010TBI) technique implemented in a pediatric population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Fifteen pediatric patients treated with myeloablative VMAT\u2010TBI between August 2019 and December 2024 were retrospectively analyzed. Prescription regimens ranged from 9.9 to 12\u00a0Gy, delivered in three to six fractions. Planning objectives followed ESTRO\u2013ACROP\u2013SIOPE recommendations, with mean lung dose less than 8\u00a0Gy and mean kidney dose less than 10\u00a0Gy. Dosimetric coverage, OAR sparing, patient\u2010specific quality assurance, image\u2010guided verification, and clinical outcomes were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All treatment plans achieved adequate target coverage (mean PTV D95% = 96.6% \u00b1 2.5%), with V110% = 19.1% \u00b1 11.2% and V120% less than 1%. Mean lung and kidney doses were 7.8 \u00b1 0.7 and 8.9 \u00b1 1.1\u00a0Gy, respectively. Planned and measured dose distributions showed excellent agreement (gamma passing rates with 3%\/3\u00a0mm criteria of 96.2% \u00b1 4.6% with ArcCHECK diode array). After a median follow\u2010up of 18\u00a0months, one late non\u2010infectious pulmonary toxicity and one severe renal toxicity were observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>VMAT\u2010TBI is a feasible, effective technique for pediatric HSCT conditioning, providing excellent target coverage, OAR sparing, and acceptable toxicity. These findings support VMAT\u2010TBI as a viable alternative to conventional TBI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1545-5017.70629","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T10:41:22Z","timestamp":1786963282000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Feasibility, Treatment Planning, and Clinical Results of VMAT\u2010Based Total Body Irradiation for Pediatric Patients: Single\u2010Center Experience"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1654-3531","authenticated-orcid":false,"given":"Soraya","family":"Mico","sequence":"first","affiliation":[{"name":"Servei d'Oncologia Radioter\u00e0pica Hospital Universitari Vall d'Hebron  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1137-7375","authenticated-orcid":false,"given":"Marcelino","family":"Hermida\u2010L\u00f3pez","sequence":"additional","affiliation":[{"name":"Servei de F\u00edsica i Protecci\u00f3 Radiol\u00f2gica Hospital Universitari Vall d'Hebron  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3424-1085","authenticated-orcid":false,"given":"M\u00f3nica","family":"Ramos\u2010Albiac","sequence":"additional","affiliation":[{"name":"Servei d'Oncologia Radioter\u00e0pica Hospital Universitari Vall d'Hebron  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Savannah","family":"Pi\u00e9\u2010Padr\u00f3","sequence":"additional","affiliation":[{"name":"Servei de F\u00edsica i Protecci\u00f3 Radiol\u00f2gica Hospital Universitari Vall d'Hebron  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9696-1386","authenticated-orcid":false,"given":"Pau","family":"Guardiola\u2010Zaragoza","sequence":"additional","affiliation":[{"name":"Servei de F\u00edsica i Protecci\u00f3 Radiol\u00f2gica Hospital Universitari Vall d'Hebron  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3272-0651","authenticated-orcid":false,"given":"Paula","family":"Navarro\u2010Palomas","sequence":"additional","affiliation":[{"name":"Servei d'Oncologia Radioter\u00e0pica Hospital Cl\u00ednic de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Jurado","sequence":"additional","affiliation":[{"name":"Servei d'Oncologia Radioter\u00e0pica Hospital Universitari Vall d'Hebron  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Servei d'Oncologia Radioter\u00e0pica Hospital Universitari Vall d'Hebron  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1840-5159","authenticated-orcid":false,"given":"Jordi","family":"Giralt","sequence":"additional","affiliation":[{"name":"Servei d'Oncologia Radioter\u00e0pica Hospital Universitari Vall d'Hebron  Barcelona Spain"},{"name":"Departament de Medicina Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"12","volume-title":"Bone Marrow Transplantation","author":"Thomas E. 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