{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:00:08Z","timestamp":1790172008450,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004099","name":"Ligue Contre le Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004099","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021564","name":"Unicancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp;amp; Cancer"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Ewing sarcoma, the second most common primary bone cancer in children, requires intensive treatment that may lead to significant long\u2010term sequelae, particularly in infants. We retrospectively analyzed data from 1621 French patients treated between 1988 and 2015 within the EW88\/93\/97 or EE99 trials, focusing on 17 infants diagnosed before 24\u00a0months of age (1% of the cohort). Their outcomes were compared to the 1245 older pediatric patients (aged 2\u201318\u00a0years). Infant Ewing sarcomas were more frequently extraosseous (29% vs. 8%,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.0037). Acute chemotherapy tolerance was comparable between infants and children under 2\u00a0years of age and older children. With a median follow\u2010up of 13.2\u00a0years (range: 7.8\u201315), adapted chemotherapy doses and reduced use of radiotherapy for local treatment, outcomes in infants were favorable, with the same rate of 88% for 5\u2010year disease\u2010free survival (DFS) and overall survival (OS). Two infants experienced localized recurrences, one of whom had undergone incomplete tumor resection without additional local treatment. At the last follow\u2010up, long\u2010term side effects were predominantly associated with local treatments, particularly surgery, rather than chemotherapy. However, given the young age of the patients, certain late toxicities (e.g., fertility impairment) remain unevaluated or could manifest in later years. Adapting chemotherapy doses to age and weight, combined with optimal local treatment, enables high survival rates in infants with Ewing sarcoma. Further monitoring is essential to assess long\u2010term sequelae as this population ages.\n                  <\/jats:p>","DOI":"10.1002\/1545-5017.70632","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T14:45:40Z","timestamp":1789051540000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ewing Sarcoma in Infants and Children Under 2 Years of Age: A French Retrospective Study"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9851-230X","authenticated-orcid":false,"given":"Elodie","family":"Verdier","sequence":"first","affiliation":[{"name":"Department of Pediatric and Adolescent Oncology Gustave Roussy  Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Cozic","sequence":"additional","affiliation":[{"name":"Biostatistics and Epidemiology Department Gustave Roussy  Villejuif 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