{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:00:13Z","timestamp":1790172013639,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["U10CA098543"],"award-info":[{"award-number":["U10CA098543"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006058","name":"St. Baldrick's Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006058","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp;amp; Cancer"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The Children's Oncology Group (COG) AREN03B2 Renal Tumor Biology and Classification Study undertook real\u2010time central reviews to enable accurate risk stratification for enrollment on therapeutic trials. The present study assessed the feasibility of the central review process on timely therapeutic protocol assignment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Procedure<\/jats:title>\n                    <jats:p>COG Renal Tumor Committee members performed real\u2010time central radiology review to assess lung metastasis and bilateral renal lesions, pathology review for histologic diagnosis and pathological stage, and surgery review to assess surgical approach and staging. An Initial Risk Assignment (IRA) was made to determine eligibility for therapeutic studies based on these reviews. An IRA within 14\u00a0days of initial procedure was required to enroll on therapeutic studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During the first\u2010generation COG therapeutic studies, AREN03B2 enrolled 2358 patients who received a study\u2010qualifying IRA. For the 2008 patients with unilateral tumors, median time from initial procedure to IRA was 12\u00a0days (IQR: 9.6\u201315.2), with 73.8% of patients receiving IRAs within 14\u00a0days from initial procedure. Median time spent in various steps of review (in sequence and\/or parallel) was: 3.0\u00a0days from initial procedure to enrollment, 1.1\u00a0days from imaging submission to central imaging review, 5.7\u00a0days from initial procedure to specimen submission to the biopathology center, 4.0\u00a0days from specimen submission to pathology review, 0.7\u00a0days from the imaging or pathology review to surgical review, and 0.1\u00a0days from surgical review completion to IRA completion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Real\u2010time central review on AREN03B2 was feasible and enabled on\u2010time enrollment onto therapeutic trials in nearly 75% of protocol\u2010eligible patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>ClinicalTrials.Gov Identifier<\/jats:title>\n                    <jats:p>NCT00898365 Aren03b2<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1545-5017.70639","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T10:52:57Z","timestamp":1787827977000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Feasibility of Real\u2010Time Central Risk Assignment for Children's Oncology Group Pediatric Renal Tumor Trials"],"prefix":"10.1002","volume":"73","author":[{"given":"Elizabeth A.","family":"Mullen","sequence":"first","affiliation":[{"name":"Dana\u2010Farber\/Boston Children's Cancer and Blood Disorders Center Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay A.","family":"Renfro","sequence":"additional","affiliation":[{"name":"Division of Biostatistics University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter F.","family":"Ehrlich","sequence":"additional","affiliation":[{"name":"Section of Pediatric Surgery University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geetika","family":"Khanna","sequence":"additional","affiliation":[{"name":"Department of Radiology &amp; Imaging Sciences Emory University School of Medicine Children's Healthcare of Atlanta  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy L.","family":"Treece","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Children's of Alabama  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric J.","family":"Gratias","sequence":"additional","affiliation":[{"name":"UnitedHealthcare Clinical Services  Minnetonka Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas G.","family":"Cost","sequence":"additional","affiliation":[{"name":"Division of Urology and the Surgical Oncology Program at the Children's Hospital of Colorado Department of Surgery University of Colorado  Denver Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul E.","family":"Grundy","sequence":"additional","affiliation":[{"name":"Division of Immunology Hematology, Oncology, Palliative Care and Environmental Interactions University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conrad V.","family":"Fernandez","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology IWK Health Centre Dalhousie University  Halifax Nova Scotia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey S.","family":"Dome","sequence":"additional","affiliation":[{"name":"Division of Oncology Children's National Hospital and the George Washington University School of Medicine and Health Sciences  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James I.","family":"Geller","sequence":"additional","affiliation":[{"name":"Peckham Center for Cancer and Blood Disorders Rady Children's Hospital  San Diego California USA"},{"name":"Division of Pediatric Hematology\/Oncology Department of Pediatrics University of California San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the AREN03B2 Study Committee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,27]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.14694\/EdBook_AM.2014.34.215"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2021.7070"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0000000000000988"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.01.2799"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.04.7852"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.17.3719"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181c0e5d7"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/1545\u20105017.70515"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.01265"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2019.05.033"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.18.01972"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.77.1931"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000002356"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.32958"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-021-11266-6"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.73.7999"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000001716"},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.30586"}],"container-title":["Pediatric Blood &amp; 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