{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:00:19Z","timestamp":1790172019733,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["CA240267"],"award-info":[{"award-number":["CA240267"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp;amp; Cancer"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Children's Oncology Group (COG) study ALTE11C1 prospectively evaluated ovarian reserve in female adolescents\/young adults (AYAs) with lymphoma from diagnosis to 1\u00a0year post\u2010end of treatment (EOT). Healthy peers provided normative comparisons.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Procedure<\/jats:title>\n                    <jats:p>From 2013 to 2018, female participants \u22656\u00a0months post\u2010menarche with newly diagnosed lymphoma were enrolled at COG institutions, along with healthy peers. All completed study entry questionnaires and menstrual cycle\u2010independent blood draws for anti\u2010M\u00fcllerian hormone (AMH), follicle\u2010stimulating hormone (FSH), and estradiol; lymphoma participants had four additional draws during and after treatment. Associations between biomarkers, disease and treatment characteristics were evaluated. Logistic regression and recursive partitioning analyses identified predictors of diminished ovarian reserve (DOR: AMH &lt;1\u00a0ng\/mL) at 1\u00a0year post\u2010EOT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Analyses included 168 participants and 125 healthy peers. Participants had lower AMH than healthy peers at study entry (2.1 vs. 4.1\u00a0ng\/mL;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.01) and 1\u00a0year post\u2010EOT (1.7 vs. 4.1\u00a0ng\/mL;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.01). AMH declined during treatment, with partial recovery post\u2010EOT to below study entry levels (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.01). Those with advanced stage Hodgkin lymphoma and\/or B symptoms had the lowest AMH. By 1\u00a0year post\u2010EOT, 34% had DOR; study entry AMH less than 1\u00a0ng\/mL (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.003) and higher alkylator exposure (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.01) were independent predictors. Most participants with study entry AMH less than 1\u00a0ng\/mL (76%) or CED \u22656.6\u00a0g\/m\n                      <jats:sup>2<\/jats:sup>\n                      (75%) demonstrated DOR at 1\u00a0year post\u2010EOT. No participant had acute ovarian failure at 1\u00a0year post\u2010EOT.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Lymphoma and its treatments affect ovarian reserve in female AYA patients. Low AMH at diagnosis and high alkylator exposure predict post\u2010therapy DOR and can guide fertility preservation counseling.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1545-5017.70641","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T13:48:50Z","timestamp":1787233730000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Longitudinal Ovarian Reserve in Female Adolescents\/Young Adults With Lymphoma: A Report From Children's Oncology Group Study ALTE11C1"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1300-1662","authenticated-orcid":false,"given":"Lindsay F.","family":"Schwartz","sequence":"first","affiliation":[{"name":"Ann &amp; Robert H. Lurie Children's Hospital of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0671-8179","authenticated-orcid":false,"given":"Clarisa R.","family":"Gracia","sequence":"additional","affiliation":[{"name":"Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9258-2698","authenticated-orcid":false,"given":"Venkatraman E.","family":"Seshan","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill P.","family":"Ginsberg","sequence":"additional","affiliation":[{"name":"Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Aplenc","sequence":"additional","affiliation":[{"name":"Children's 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