{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:59:41Z","timestamp":1790402381576,"version":"4.1.0"},"reference-count":70,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Adolescents with high\u2010risk cancer face complex developmental, psychosocial, and ethical challenges that extend beyond disease\u2010directed treatment. Although international recommendations exist for communication, psychosocial care, pediatric palliative care, survivorship, and shared decision\u2010making, these have largely evolved within individual domains rather than as an integrated operational approach tailored to adolescents with high\u2010risk disease. We therefore developed evidence\u2010informed multidisciplinary consensus guidance to support psychosocial care across pediatric oncology settings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The guidance was developed through a multidisciplinary initiative of the Italian Association of Pediatric Hematology and Oncology (AIEOP), with leading experts in psycho\u2010oncology, the medical and psychological care of adolescents, palliative and supportive care, and representatives from 12 pediatric oncology centers. A structured review of the literature and existing international guidance informed iterative multidisciplinary consensus. Recommendations integrated empirical evidence, international guidance, and multidisciplinary clinical expertise. To enhance transparency, recommendations were categorized as evidence\u2010informed recommendations, consensus\u2010based recommendations, or good practice statements, with recommendation\u2010level traceability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The consensus process produced operational guidance organized into four domains: (1) core practice recommendations; (2) decision\u2010making capacity and progressive assent; (3) routine psychosocial screening and stepped care; and (4) implementation and quality improvement. The guidance emphasizes developmentally appropriate communication, progressive adolescent participation in decision\u2010making, systematic psychosocial assessment, family\u2010centered care, educational continuity, timely integration of supportive and pediatric palliative care, and implementation strategies that support equitable, coordinated multidisciplinary care while allowing adaptation to local contexts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This AIEOP evidence\u2010informed multidisciplinary consensus guidance complements existing international recommendations by integrating evidence, established guidance, and multidisciplinary expertise into practical operational recommendations, providing a transparent foundation for consistent, equitable, and developmentally appropriate psychosocial care and future implementation evaluation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1545-5017.70668","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T08:46:59Z","timestamp":1790153219000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evidence\u2010Informed Multidisciplinary Consensus Guidance for the Psychosocial Care of Adolescents With High\u2010Risk Cancer: Recommendations From the Italian Association of Pediatric Hematology and Oncology"],"prefix":"10.1002","author":[{"given":"Johanna M. C.","family":"Blom","sequence":"first","affiliation":[{"name":"Department of Biomedical Metabolic and Neural Sciences University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorella","family":"Scarponi","sequence":"additional","affiliation":[{"name":"Pediatric Unit IRCCS Azienda Ospedaliero\u2010Universitaria Di Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1437-3572","authenticated-orcid":false,"given":"Giulia","family":"Zucchetti","sequence":"additional","affiliation":[{"name":"Pediatric Oncology Division Regina Margherita Children's Hospital AOU City of Health and Science  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5289-3037","authenticated-orcid":false,"given":"Teresa","family":"Perillo","sequence":"additional","affiliation":[{"name":"UOC Department of Pediatrics, Onco\u2010Hematology University Hospital Policlinico Di Bari  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Montanaro","sequence":"additional","affiliation":[{"name":"Complex Structure of Pediatrics and Pediatric Oncohematology \u201cNadia Toffa\u201d Central Hospital Santissima Annunziata  Taranto Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6722-8390","authenticated-orcid":false,"given":"Elisa","family":"Marconi","sequence":"additional","affiliation":[{"name":"Clinical Psychology Unit Fondazione Policlinico Universitario A. Gemelli IRCCS Catholic University of the Sacred Heart  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Rutigliano","sequence":"additional","affiliation":[{"name":"UOC Department of Pediatrics, Onco\u2010Hematology University Hospital Policlinico Di Bari  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5399-5070","authenticated-orcid":false,"given":"Paolo","family":"Colavero","sequence":"additional","affiliation":[{"name":"UOSVD Psicologia Ospedaliera Vito Fazzi, ASL  Lecce Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1940-7375","authenticated-orcid":false,"given":"Paola","family":"Quarello","sequence":"additional","affiliation":[{"name":"Pediatric Oncology Division Regina Margherita Children's Hospital AOU City of Health and Science  Turin Italy"},{"name":"Department of Paediatric and Public Health Sciences University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Bertolotti","sequence":"additional","affiliation":[{"name":"Pediatric Oncology Division Regina Margherita Children's Hospital AOU City of Health and Science  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Cellini","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Pediatric Oncology Unit University Hospital Policlinico Di Modena  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Clerici","sequence":"additional","affiliation":[{"name":"Pediatric Oncology Unit Fondazione IRCCS Istituto Nazionale Dei Tumori  Milan Italy"},{"name":"Department of Oncology and Hemato\u2010oncology University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2828-0257","authenticated-orcid":false,"given":"Maurizio","family":"Mascarin","sequence":"additional","affiliation":[{"name":"Centro di Riferimento Oncologico IRCCS  Aviano Pordenone Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Bomben","sequence":"additional","affiliation":[{"name":"Centro di Riferimento Oncologico IRCCS  Aviano Pordenone Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4724-0517","authenticated-orcid":false,"given":"Andrea","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Pediatric Oncology Unit Fondazione IRCCS Istituto Nazionale Dei Tumori  Milan Italy"},{"name":"Department of Oncology and Hemato\u2010oncology University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the expert workgroup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,23]]},"reference":[{"key":"e_1_2_14_2_1","first-page":"606","article-title":"The Developing Social Brain: Adolescence as a Sensitive Period","volume":"19","author":"Blakemore S.\u2010J.","year":"2018","journal-title":"Nature Reviews Neuroscience"},{"key":"e_1_2_14_3_1","first-page":"93","article-title":"Experience During Adolescence Shapes Brain Development: From Synaptic Pruning to Reward Circuitry","volume":"101","author":"Dow\u2010Edwards D.","year":"2019","journal-title":"Neuroscience and Biobehavioral Reviews"},{"key":"e_1_2_14_4_1","first-page":"167","article-title":"Distress and Adjustment Among Adolescents and Young Adults With Cancer: An Empirical and Conceptual Review","volume":"2","author":"Sansom\u2010Daly U. 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