{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T12:02:20Z","timestamp":1789646540869,"version":"4.0.0"},"reference-count":20,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004160","name":"Mazandaran University of Medical Sciences","doi-asserted-by":"publisher","award":["IRMAZUMS20180"],"award-info":[{"award-number":["IRMAZUMS20180"]}],"id":[{"id":"10.13039\/501100004160","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood & Cancer"],"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Anxiety is prevalent in children with cancer and can impair treatment adherence, outcomes, and quality of life. Chemotherapy often increases anxiety, potentially worsening complications like nausea, vomiting, and poor cooperation. This study investigated the efficacy of olanzapine in mitigating chemotherapy\u2010induced anxiety in pediatric cancer patients.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This pilot randomized, double\u2010blind, placebo\u2010controlled trial enrolled pediatric patients with cancer. Participants were randomly assigned to receive either olanzapine or placebo, with one daily dose administered from 2 days prior to 3 days following chemotherapy, totaling five doses. Anxiety was measured at baseline, on the day of chemotherapy, and at the end of treatment using the Spence Children's Anxiety Scale (SCAS) and Visual Analog Scale (VAS) for anxiety; nausea and vomiting were graded per Common Terminology Criteria for Adverse Events (CTCAE).<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Between July 2024 and September 2025, 30 pediatric cancer patients (mean age 11.10\u00a0\u00b1\u00a02.59 years; 63% female) were enrolled and analyzed, with no significant demographic differences. SCAS scores showed a significant anxiety reduction in the olanzapine group post\u2010intervention (\n p<\/jats:italic>\n \u00a0=\u00a00.01) but not in the placebo group (\n p<\/jats:italic>\n \u00a0=\u00a00.428). VAS anxiety scores did not differ significantly between groups, though the overall 5\u2010day trend favored olanzapine. The olanzapine group also experienced improvements in nausea severity and vomiting frequency. Adverse effects were mild and transient.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n This pilot trial suggests that olanzapine may be both safe and effective in mitigating chemotherapy\u2010related anxiety in pediatric cancer patients. These findings indicate its potential as an adjunct to current anxiety\u2010management protocols. Further large\u2010scale, confirmatory studies with extended follow\u2010up are necessary to validate these results and evaluate long\u2010term outcomes.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/1545-5017.70684","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T11:10:23Z","timestamp":1789643423000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Olanzapine on Chemotherapy\u2010Related Anxiety in Pediatric Cancer Patients: A Pilot Study"],"prefix":"10.1002","author":[{"given":"Zahra","family":"Sahraee","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy, Faculty of Pharmacy Mazandaran University of Medical Sciences Sari Mazandaran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Naderisorki","sequence":"additional","affiliation":[{"name":"Thalassemia Research Center (TRC), Hemoglobinopathy Institute Mazandaran University of Medical Sciences Sari Mazandaran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7444-6732","authenticated-orcid":false,"given":"Monireh","family":"Ghazaeian","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences Research Center, Department of Clinical Pharmacy, Faculty of Pharmacy Mazandaran University of Medical Sciences Sari Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samaneh","family":"Farnia","sequence":"additional","affiliation":[{"name":"Psychiatry and Behavioral Sciences Research Center, Addiction Institute and Department of Psychiatry, Faculty of Medicine Mazandaran University of Medical Sciences Sari Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0549-1788","authenticated-orcid":false,"given":"Abolfazl","family":"Hosseinnataj","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Faculty of Health Mazandaran University of Medical Sciences Sari Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0355-4370","authenticated-orcid":false,"given":"Hossein","family":"Kasiri","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, Faculty of Pharmacy Mazandaran University of Medical Sciences Sari Mazandaran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammadreza","family":"Rafati","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences Research Center, Department of Clinical Pharmacy, Faculty of Pharmacy Mazandaran University of Medical Sciences Sari Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaghayegh","family":"Mohammadzadeh","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, Faculty of Pharmacy Mazandaran University of Medical Sciences Sari Mazandaran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,17]]},"reference":[{"issue":"2","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.soncn.2007.01.001","article-title":"Symptom Clusters in Children With Cancer","volume":"23","author":"Hockenberry M.","year":"2007","journal-title":"Seminars in Oncology Nursing"},{"issue":"6","key":"e_1_2_10_3_1","first-page":"608","article-title":"[Chemotherapy\u2010Induced Nausea and Vomiting in Pediatric Oncology Patients: 2023 Recommendations From the Supportive Care Committee of the French Society of Cancer in Children and Adolescents]","volume":"111","author":"Renaux Torres M. 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