{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T11:13:15Z","timestamp":1790248395006,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Loneliness is associated with adverse physical and mental health outcomes and remains understudied in children and adolescents undergoing cancer therapy. Pediatric oncology patients may be at increased risk due to medical isolation and disruption of social networks.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We conducted a cross\u2010sectional, mixed\u2010methods study of children and adolescents and young adults (AYA) receiving active cancer treatment and peers without chronic medical conditions. Participants completed surveys assessing loneliness using the Revised UCLA Loneliness Scale (RULS\u20108), emotional distress, and social connection strategies. Qualitative thematic analysis was performed on open\u2010ended responses to identify subject\u2010reported contributors to loneliness and mitigation strategies.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Sixty\u2010six participants were enrolled, equally divided between oncologic and non\u2010oncologic groups. Overall, 15% met criteria for loneliness, 70% of whom were receiving cancer therapy. Although loneliness prevalence did not differ by cancer status, oncology patients self\u2010reported significantly higher depressive symptoms (\n p<\/jats:italic>\n = 0.0281) and greater perceived burden of loneliness (\n p<\/jats:italic>\n = 0.0432). Social interaction was widely identified as protective against loneliness, and oncology patients more frequently identified social media as a strategy to reduce loneliness relative to non\u2010oncologic patients (58%\u00a0vs. 20%). Qualitative analysis identified physical isolation, emotional isolation, and social exclusion as primary contributors to loneliness, with \u201cmedical exclusion\u201d as a unique theme among oncology patients.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n While cancer diagnosis alone did not predict loneliness, pediatric oncology patients experienced greater depressive symptoms and adverse effects associated with loneliness. Screening for loneliness and supporting adaptive social connection strategies may represent important opportunities for pediatric hematology\/oncology and primary care providers to improve psychosocial care during and after cancer therapy.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/1545-5017.70689","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:48:44Z","timestamp":1790246924000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bridging the Loneliness Gap: Depression, Connectivity, and Isolation in Pediatric Oncology Patients and Their Peers"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6433-3117","authenticated-orcid":false,"given":"Charlotte N.","family":"Stahlfeld","sequence":"first","affiliation":[{"name":"University of Pittsburgh Medical Center Mercy Hospital Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5074-1219","authenticated-orcid":false,"given":"Scott H.","family":"Maurer","sequence":"additional","affiliation":[{"name":"Division of Pediatric Palliative Medicine and Supportive Care University of Pittsburgh School of Medicine UPMC Children's Hospital of Pittsburgh Pittsburgh Pennsylvania USA"},{"name":"Division of Pediatric Hematology\/Oncology University of Pittsburgh School of Medicine UPMC Children's Hospital of Pittsburgh Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle D.","family":"Watkinson","sequence":"additional","affiliation":[{"name":"Division of Pediatric Palliative Medicine and Supportive Care University of Pittsburgh School of Medicine UPMC Children's Hospital of Pittsburgh Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5204-117X","authenticated-orcid":false,"given":"John","family":"Nury","sequence":"additional","affiliation":[{"name":"Franklin and Marshall College Lancaster Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7930-9517","authenticated-orcid":false,"given":"Elise","family":"Barberis","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4978-0895","authenticated-orcid":false,"given":"Molly C.","family":"Mack","sequence":"additional","affiliation":[{"name":"Division of Pediatric Palliative Medicine and Supportive Care University of Pittsburgh School of Medicine UPMC Children's Hospital of Pittsburgh Pittsburgh Pennsylvania USA"},{"name":"Division of Pediatric Hematology\/Oncology University of Pittsburgh School of Medicine UPMC Children's Hospital of Pittsburgh Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-0-12-394388-0.00001-0","article-title":"Loneliness in Childhood: Toward the Next Generation of Assessment and Research","volume":"42","author":"Weeks M.","year":"2012","journal-title":"Advances in Child Development and Behavior"},{"issue":"1","key":"e_1_2_8_3_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0190033","article-title":"Association of Loneliness with all\u2010cause Mortality: A Meta\u2010analysis","volume":"13","author":"Rico\u2010Uribe L. 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