{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T13:07:35Z","timestamp":1789564055819,"version":"build-2803163510"},"reference-count":11,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100008175","name":"Glasgow Children's Hospital Charity","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008175","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001273","name":"CHILDREN with CANCER UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001273","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp;amp; Cancer"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Central and peripheral neurotoxicity after methotrexate is a rare but challenging complication of therapy for pediatric lymphoid malignancies. In this Ponte\u2010di\u2010Legno Toxicity Working Group and international Berlin\u2010Frankfurt\u2010M\u00fcnster Group study, we describe nine children and adolescents with transverse myelitis (\n                    <jats:italic>n<\/jats:italic>\n                    = 6) or Guillain\u2013Barr\u00e9 syndrome (\n                    <jats:italic>n<\/jats:italic>\n                    = 3) after chemotherapy that included methotrexate. All transverse myelitis cases but one occurred in lymphoma patients with central nervous system status 3\u2010disease, and early imaging and cerebrospinal fluid findings frequently failed to distinguish the two entities. Three patients died from the toxicity, and all survivors of transverse myelitis had permanent deficits. Re\u2010exposure to intrathecal chemotherapy produced more severe recurrences and should therefore be avoided.\n                  <\/jats:p>","DOI":"10.1002\/1545-5017.70695","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T12:34:48Z","timestamp":1789562088000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Transverse Myelitis and Guillain\u2013Barr\u00e9 Syndrome in Pediatric Lymphoid Malignancies: An International Retrospective Study"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9061-0504","authenticated-orcid":false,"given":"Sebastian K.","family":"Eder","sequence":"first","affiliation":[{"name":"Department of Pediatric Hematology and Oncology St. Anna Children's Hospital Medical University of Vienna  Vienna Austria"},{"name":"St. Anna Children's Cancer Research Institute (CCRI)  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6193-5201","authenticated-orcid":false,"given":"Peter E. L.","family":"Pontoppidan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, Rigshospitalet, University Hospital Copenhagen, and Institute of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6675-867X","authenticated-orcid":false,"given":"Elisa","family":"Carraro","sequence":"additional","affiliation":[{"name":"Pediatric Hematology, Oncology and Stem Cell Transplant Division, Department of Women's and Children's Health University of Padua  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Winther","family":"Gunnes","sequence":"additional","affiliation":[{"name":"Pediatric Oncology Department Haukeland University Hospital  Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5449-5246","authenticated-orcid":false,"given":"Christina","family":"Halsey","sequence":"additional","affiliation":[{"name":"Wolfson Wohl Cancer Research Centre, School of Cancer Sciences College of Medical Veterinary and Life Sciences University of Glasgow  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5186-3365","authenticated-orcid":false,"given":"Lisa L.","family":"Hjalgrim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, Rigshospitalet, University Hospital Copenhagen, and Institute of Clinical Medicine University of Copenhagen  Copenhagen Denmark"},{"name":"Pediatric Oncology Research Laboratory Department of Pediatrics and Adolescent Medicine Rigshospitalet University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3437-8338","authenticated-orcid":false,"given":"Liv","family":"Andres\u2010Jensen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, Rigshospitalet, University Hospital Copenhagen, and Institute of Clinical Medicine University of Copenhagen  Copenhagen Denmark"},{"name":"Pediatric Oncology Research Laboratory Department of Pediatrics and Adolescent Medicine Rigshospitalet University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Pillon","sequence":"additional","affiliation":[{"name":"Pediatric Hematology, Oncology and Stem Cell Transplant Division, Department of Women's and Children's Health University of Padua  Padua 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Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9285-6898","authenticated-orcid":false,"given":"Andishe","family":"Attarbaschi","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology St. Anna Children's Hospital Medical University of Vienna  Vienna Austria"},{"name":"St. Anna Children's Cancer Research Institute (CCRI)  Vienna 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