{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T13:08:33Z","timestamp":1789564113908,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp;amp; Cancer"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Patients with refractory or relapsed T\u2010cell acute lymphoblastic leukemia (R\/R T\u2010ALL) have dismal outcomes. While immunotherapies are growing opportunities for B\u2010cell ALL, targeted therapies for T\u2010ALL remain limited. The CD38 antigen, steadily expressed on T\u2010ALL blasts, represents a relevant therapeutic target. Daratumumab, an anti\u2010CD38 monoclonal antibody routinely used in other hematologic malignancies, could be a promising treatment option for T\u2010ALL. We report here the achievement of a third complete response with the combination of daratumumab, high\u2010dose cytarabine (18\u00a0g\/m\n                    <jats:sup>2<\/jats:sup>\n                    ), and amsacrine in an 11\u2010year\u2010old patient with highly aggressive relapsed T\u2010ALL, enabling subsequent allogeneic hematopoietic stem cell transplantation.\n                  <\/jats:p>","DOI":"10.1002\/1545-5017.70705","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T12:40:31Z","timestamp":1789562431000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Daratumumab in Combination With High\u2010Dose Cytarabine and Amsacrine as an Effective Salvage Therapy and Bridge to Allogeneic Hematopoietic Stem Cell Transplantation for Refractory T\u2010Cell Acute Lymphoblastic Leukemia: A Case Report"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5274-8031","authenticated-orcid":false,"given":"Perrine","family":"Moyer","sequence":"first","affiliation":[{"name":"Department of Hematology Nantes University Hospital  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5148-3792","authenticated-orcid":false,"given":"Baptiste Le","family":"Calvez","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hemato\u2010Immunology Robert Debre University Hospital, APHP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4070-3694","authenticated-orcid":false,"given":"Caroline","family":"Mayeur\u2010Rousse","sequence":"additional","affiliation":[{"name":"Department of Biological Hematology Nantes University Hospital  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1547-8229","authenticated-orcid":false,"given":"Audrey","family":"Grain","sequence":"additional","affiliation":[{"name":"Pediatric Hematology and Oncology Department Nantes University Hospital, Inserm, CIC 1413  Nantes France"},{"name":"Nantes Universit\u00e9, Inserm UMR 1307, CNRS UMR 6075, CRCI2NA, Team 12  Nantes France"},{"name":"Nantes University Hospital, CIC FEA  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1400972"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(19)30031\u20102"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2008.251"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023023754"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010024\u201007807\u20100"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023022920"},{"issue":"25","key":"e_1_2_10_8_1","first-page":"3019","article-title":"How I Treat Newly Diagnosed and Refractory T\u2010cell Acute Lymphoblastic Lymphoma in Children and Young Adults","volume":"141","author":"Ford J. 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