{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:14:46Z","timestamp":1789992886184,"version":"4.0.1"},"reference-count":20,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp;amp; Cancer"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Numerous international studies have reported declines in new cancer diagnoses, delayed diagnoses and disruptions in cancer treatment following the implementation of COVID\u201019 pandemic public health measures, raising concerns that these effects may ultimately contribute to increased cancer mortality. We conducted one of the first population\u2010based assessments of the impact of the COVID\u201019 pandemic on childhood cancer survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Procedure<\/jats:title>\n                    <jats:p>\n                      Using data from the national German Childhood Cancer Registry, we identified all children aged 0\u201314 years with a new cancer diagnosis in Germany between 2015 and 2023 (\n                      <jats:italic>N<\/jats:italic>\n                      = 16,664) and compared early mortality (death within 90 days after diagnosis) and 3\u2010year overall survival (OS) during the pandemic with the respective pre\u2010pandemic patterns (2015\u20132019).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We found no indications of adverse effects of the pandemic on childhood cancer survival in Germany. Early mortality was already low in the pre\u2010pandemic period at 1.5% for childhood cancer overall, and decreased slightly during the pandemic, with reductions seen for virtually all diagnostic groups. This decline was most pronounced in 2020, when overall early mortality among children with cancer fell to 0.7%. Three\u2010year OS slightly increased for childhood cancer overall, from 88.8% in 2015\u20132019 to 90.3% in 2021, with increases observed for most diagnostic groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Unlike other international studies reporting both reduced access to care and care interruptions among children with cancer during the pandemic, worse in low\u2010 and middle\u2010income countries, these findings from Germany showed no evidence of adverse effects on childhood cancer survival, highlighting the resilience of the healthcare system in this context.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1545-5017.70706","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T11:49:15Z","timestamp":1789991355000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Impact of the COVID\u201019 Pandemic on Childhood Cancer Survival: A Population\u2010Based Assessment of Survival Patterns Between 2015 and 2023 in Germany"],"prefix":"10.1002","author":[{"given":"Friederike","family":"Erdmann","sequence":"first","affiliation":[{"name":"Research Group Aetiology and Inequalities in Childhood Cancer Division of Childhood Cancer Epidemiology Institute of Medical Biostatistics Epidemiology and Informatics (IMBEI) University Medical Center of the Johannes Gutenberg University  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maike","family":"Wellbrock","sequence":"additional","affiliation":[{"name":"Research Group Aetiology and Inequalities in Childhood Cancer Division of Childhood Cancer Epidemiology Institute of Medical Biostatistics Epidemiology and Informatics (IMBEI) University Medical Center of the Johannes Gutenberg University  Mainz Germany"},{"name":"Department of Prevention and Evaluation Leibniz Institute for Prevention Research and Epidemiology \u2013 BIPS  Bremen Germany"},{"name":"Unit of Epidemiology Institute of Environmental Medicine Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Louro","sequence":"additional","affiliation":[{"name":"Unit of Epidemiology Institute of Environmental Medicine Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arndt","family":"Borkhardt","sequence":"additional","affiliation":[{"name":"Department of Paediatric Oncology Haematology and Clinical Immunology Medical Faculty Heinrich Heine University  D\u00fcsseldorf Germany"},{"name":"German Cancer Consortium (DKTK) Partnering Site Essen\/D\u00fcsseldorf  D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Schrappe","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University Hospital Schleswig\u2010Holstein  Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Tr\u00fcbenbach","sequence":"additional","affiliation":[{"name":"Division of Childhood Cancer Epidemiology\/German Childhood Cancer Registry Institute of Medical Biostatistics Epidemiology and Informatics (IMBEI) University Medical Center of the Johannes Gutenberg University  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desiree","family":"Grabow","sequence":"additional","affiliation":[{"name":"Division of Childhood Cancer Epidemiology\/German Childhood Cancer Registry Institute of Medical Biostatistics Epidemiology and Informatics (IMBEI) University Medical Center of the Johannes Gutenberg University  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile M.","family":"Ronckers","sequence":"additional","affiliation":[{"name":"Division of Childhood Cancer Epidemiology\/German Childhood Cancer Registry Institute of Medical Biostatistics Epidemiology and Informatics (IMBEI) University Medical Center of the Johannes Gutenberg University  Mainz Germany"},{"name":"Division of CAYA Cancer Survivorship Research, German Cancer Research Center  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Sch\u00fcz","sequence":"additional","affiliation":[{"name":"Environment and Lifestyle Epidemiology Branch, International Agency for Research on Cancer World Health Organization (IARC\/WHO)  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,21]]},"reference":[{"issue":"5","key":"e_1_2_13_2_1","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/S1470-2045(24)00154-2","article-title":"1 in 9 USA Cancer Diagnoses Missed During 2020 COVID\u201019 Pandemic","volume":"25","author":"Kirby T.","year":"2024","journal-title":"Lancet Oncology"},{"key":"e_1_2_13_3_1","unstructured":"H. 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P.Kluge \u201cCancer Services Disrupted by up to 50% in All Countries Reporting: A Deadly Impact of COVID\u201019 \u201d World Health Organization published February 3 2022 https:\/\/www.who.int\/europe\/news\/item\/03\u201002\u20102022\u2010cancer\u2010services\u2010disrupted\u2010by\u2010up\u2010to\u201050\u2010in\u2010all\u2010countries\u2010reporting\u2010a\u2010deadly\u2010impact\u2010of\u2010covid\u201019."},{"issue":"5","key":"e_1_2_13_4_1","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/S2352-4642(21)00031-6","article-title":"Global Effect of the COVID\u201019 Pandemic on Paediatric Cancer Care: A Cross\u2010Sectional Study","volume":"5","author":"Graetz D.","year":"2021","journal-title":"Lancet Child & Adolescent Health"},{"issue":"2","key":"e_1_2_13_5_1","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1111\/apa.15576","article-title":"Observed Reduction in the Diagnosis of Acute Lymphoblastic Leukaemia in Children During the COVID\u201019 Pandemic","volume":"110","author":"Jarvis K. 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Cary NC USA;2016."},{"issue":"3","key":"e_1_2_13_18_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1004934","article-title":"Childhood Cancer in Sweden During the COVID\u201019 Pandemic: Temporal Patterns in Incidence and Survival in a Nationwide Register\u2010based Cohort Study","volume":"23","author":"Kampitsi C. 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