{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:59:15Z","timestamp":1790765955636,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Anti\u2011GD2 immunotherapy with dinutuximab beta improves survival in patients with high\u2011risk neuroblastoma but usually requires prolonged inpatient administration, with a negative impact on quality of life and family well\u2011being. This study aimed to evaluate the feasibility and safety of a structured home\u2011based administration supported by telemonitoring, and its impact on psychological distress, quality of life, and caregiver perception of care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Procedure<\/jats:title>\n                    <jats:p>Between May 2025 and March 2026, all consecutive pediatric and young adult patients (2\u201320 years) eligible for home\u2011based dinutuximab beta administration were prospectively included. Treatment followed a stepwise protocol with an initial inpatient phase and subsequent continuation at home supported by remote telemonitoring. Psychological distress was assessed using the Distress Thermometer at three time points, and quality of life using the KIDSCREEN\u201110 questionnaire. Safety was monitored through remote assessment of vital signs according to Pediatric Early Warning System criteria and adverse event reporting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eleven patients were included. Psychological distress decreased over time in both age groups (2\u20137 years: median score from 5.5 to 2; 8\u201320 years: from 6 to 1). Quality\u2011of\u2011life scores improved across multiple domains. Telemonitoring showed stable vital parameters, with no treatment\u2011related severe adverse events. One hospitalization was reported due to a central venous catheter infection unrelated to therapy. Caregiver satisfaction was high, with most families reporting increased perceived safety.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Home\u2011based dinutuximab beta administration supported by telemonitoring is feasible and safe and is associated with reduced psychological distress and improved quality of life, representing a patient\u2011 and family\u2011centered model of care in pediatric oncology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1545-5017.70718","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:09:02Z","timestamp":1790762942000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Home\u2010Based, Connected Care: Dinutuximab Beta Immunotherapy in Neuroblastoma Beyond Feasibility. Improving Quality of Life and Family Satisfaction"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2025-9741","authenticated-orcid":false,"given":"Matteo","family":"Amicucci","sequence":"first","affiliation":[{"name":"Area of Hematology\u2010Oncology, Cell Therapy, Gene Therapies, and Hematopoietic Transplantation Bambino Ges\u00f9 Children's Hospital IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adele","family":"Rip\u00e0","sequence":"additional","affiliation":[{"name":"Area of Hematology\u2010Oncology, Cell Therapy, Gene Therapies, and Hematopoietic Transplantation Bambino Ges\u00f9 Children's Hospital IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Italo","family":"Ciaralli","sequence":"additional","affiliation":[{"name":"Area of Hematology\u2010Oncology, Cell Therapy, Gene Therapies, and Hematopoietic Transplantation Bambino Ges\u00f9 Children's Hospital IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4570-8503","authenticated-orcid":false,"given":"Manuela","family":"Mampieri","sequence":"additional","affiliation":[{"name":"Area of Hematology\u2010Oncology, Cell Therapy, Gene Therapies, and Hematopoietic Transplantation Bambino Ges\u00f9 Children's Hospital IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8520-8008","authenticated-orcid":false,"given":"Andrea","family":"De Salvo","sequence":"additional","affiliation":[{"name":"Area of Hematology\u2010Oncology, Cell Therapy, Gene Therapies, and Hematopoietic Transplantation Bambino Ges\u00f9 Children's Hospital IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4408-2373","authenticated-orcid":false,"given":"Angela","family":"Mastronuzzi","sequence":"additional","affiliation":[{"name":"Area of Hematology\u2010Oncology, Cell Therapy, Gene Therapies, and Hematopoietic Transplantation Bambino Ges\u00f9 Children's Hospital IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Di Giannatale","sequence":"additional","affiliation":[{"name":"Area of Hematology\u2010Oncology, Cell Therapy, Gene Therapies, and Hematopoietic Transplantation Bambino Ges\u00f9 Children's Hospital IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2505-9888","authenticated-orcid":false,"given":"Annalisa","family":"Serra","sequence":"additional","affiliation":[{"name":"Area of Hematology\u2010Oncology, Cell Therapy, Gene Therapies, and Hematopoietic Transplantation Bambino Ges\u00f9 Children's Hospital IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Antonietta","family":"De Ioris","sequence":"additional","affiliation":[{"name":"Area of Hematology\u2010Oncology, Cell Therapy, Gene Therapies, and Hematopoietic Transplantation Bambino Ges\u00f9 Children's Hospital IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571\u2010022\u201000643\u2010z"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(18)30578\u20103"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0911123"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201020\u20103909"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010024\u201009135\u20105"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40272\u2010021\u201000469\u20109"},{"key":"e_1_2_14_8_1","volume-title":"High\u2010Risk Neuroblastoma Study 2 of SIOP\u2010Europe\u2010Neuroblastoma (SIOPEN) (NCT04221035)","author":"ClinicalTrials.gov","year":"2019"},{"key":"e_1_2_14_9_1","unstructured":"EUSA Pharma Outpatient Administration Qarziba\u00ae (Dinutuximab Beta) (MI\u2010EUR\u201000126 v1.0)(EUSA Pharma 2026)."},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/NAN.0000000000000409"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20940"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1586\/14737167.5.3.353"},{"key":"e_1_2_14_13_1","unstructured":"EasyMed EasyMed Telemonitoring Platform. 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