{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:56:02Z","timestamp":1790765762749,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100018719","name":"Ko\u00e7 \u00dcniversitesi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018719","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Children undergoing cancer treatment experience high anxiety, procedural distress, and impaired quality of life (QoL), yet scalable psychosocial interventions remain scarce. We tested whether an augmented reality (AR)\u2013supported, manualized cognitive behavioral therapy program (AR\u2010CBT; the \u201cMy Hospital Buddy Ida\u201d application plus a workbook) improves psychosocial outcomes more than standard CBT or usual care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Procedure<\/jats:title>\n                    <jats:p>In a multicenter, three\u2010arm, assessor\u2010blinded randomized controlled trial at six recruiting sites in T\u00fcrkiye, 114 children aged 6\u201312 years within the first 4 months of chemotherapy were randomized to AR\u2010CBT, standard CBT (workbook only), or usual care; both active arms received nine clinician\u2010delivered sessions. The primary outcome was the child\u2010reported Pediatric Quality of Life Inventory (PedsQL) Cancer Module total score. Pre\u2010specified secondary outcomes included resilience, parent\u2010reported behavior problems, state anxiety, parent\u2010proxy QoL, and anticipatory fatigue, nausea, and distress. Analyses adjusted for baseline and age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Ninety\u2010three children completed the trial (AR\u2010CBT\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a036; standard CBT\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a028; usual care\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a029). AR\u2010CBT yielded higher post\u2010treatment PedsQL total scores than both comparators (\n                      <jats:italic>F<\/jats:italic>\n                      [2,88]\u00a0=\u00a012.98,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001, partial\n                      <jats:italic>\u03b7<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a00.23), with parallel gains across most subscales. Resilience was higher after AR\u2010CBT (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), parent\u2010reported anxiety problems decreased (\n                      <jats:italic>F<\/jats:italic>\n                      \u00a0=\u00a05.75,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.004), and anticipatory fatigue, nausea, and distress all declined (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0\u2264\u00a00.014). Acceptability was high in all arms (97.2% in AR\u2010CBT; between\u2010arm differences nonsignificant).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>AR\u2010supported CBT was feasible, acceptable, and superior to standard CBT and usual care for QoL, resilience, and symptom\u2010related distress, supporting AR\u2010CBT as a scalable vehicle for evidence\u2010based psychotherapy in pediatric oncology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>ClinicalTrials.gov: NCT07742059 (first submitted July 21, 2026, first posted August 3, 2026). Enrollment began in April 2024, so registration was retrospective. The study design and primary outcome were pre\u2010specified in the Institutional Review Board (IRB)\u2010approved protocol (2023.128.IRB1.040, approved April 12, 2023) before enrollment began.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1545-5017.70721","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T09:59:27Z","timestamp":1790762367000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Augmented Reality\u2013Supported Cognitive Behavioral Therapy for Children With Cancer: A Multicenter, Three\u2010Arm Randomized Controlled Trial"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6873-8234","authenticated-orcid":false,"given":"Tuba","family":"Mutluer","sequence":"first","affiliation":[{"name":"Department of Child and Adolescent Psychiatry Akdeniz University School of Medicine  Antalya T\u00fcrkiye"},{"name":"Ko\u00e7 University Research Center for Translational Medicine (KUTTAM) Ko\u00e7 University  Istanbul T\u00fcrkiye"},{"name":"Graduate School of Health Sciences Neuroscience Program Ko\u00e7 University  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asl\u0131han","family":"\u00d6zcan Morey","sequence":"additional","affiliation":[{"name":"Ko\u00e7 University Hospital  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pelin","family":"Karaturhan","sequence":"additional","affiliation":[{"name":"KUAR\u2013KARMA Reality Laboratory Ko\u00e7 University  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1130-999X","authenticated-orcid":false,"given":"Herdem","family":"Aslan Gen\u00e7","sequence":"additional","affiliation":[{"name":"Ko\u00e7 University Research Center for Translational Medicine (KUTTAM) Ko\u00e7 University  Istanbul T\u00fcrkiye"},{"name":"Department of Child and Adolescent Psychiatry Ko\u00e7 University School of Medicine (KUSOM)  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romina","family":"Markaro\u011flu Elvan","sequence":"additional","affiliation":[{"name":"Ko\u00e7 University Hospital  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatih","family":"Erbey","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Hematology\u2010Oncology Ko\u00e7 University Hospital  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nur\u015fah","family":"Eker","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\u2010Oncology Pendik Training and Research Hospital Marmara University  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alphan","family":"K\u00fcpesiz","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology and Oncology Akdeniz University Faculty of Medicine  Antalya T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2513-7188","authenticated-orcid":false,"given":"Funda","family":"Tayfun K\u00fcpesiz","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology and Oncology Akdeniz University Faculty of Medicine  Antalya T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elif","family":"G\u00fcler","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology and Oncology Akdeniz University Faculty of Medicine  Antalya T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"As\u0131m Evren","family":"Yanta\u00e7","sequence":"additional","affiliation":[{"name":"KUAR\u2013KARMA Reality Laboratory Ko\u00e7 University  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Kemal","family":"Ku\u015fcu","sequence":"additional","affiliation":[{"name":"Ko\u00e7 University School of Medicine (KUSOM)  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4344-8174","authenticated-orcid":false,"given":"Rejin","family":"Kebudi","sequence":"additional","affiliation":[{"name":"Ko\u00e7 University School of Medicine (KUSOM)  Istanbul T\u00fcrkiye"},{"name":"Division of Pediatric Hematology\u2010Oncology Istanbul University Oncology Institute  Istanbul T\u00fcrkiye"},{"name":"Division of Pediatric Hematology\u2010Oncology American Hospital  Istanbul 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