{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:06:40Z","timestamp":1790762800870,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000102","name":"Health Resources and Services Administration","doi-asserted-by":"publisher","award":["T32HP10027"],"award-info":[{"award-number":["T32HP10027"]}],"id":[{"id":"10.13039\/100000102","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K07 CA200668"],"award-info":[{"award-number":["K07 CA200668"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001422","name":"American Society of Hematology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001422","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>As adolescents and young adults (AYAs) with cancer gain independence in managing their care, social support may influence their health behaviors, including medication adherence. This study examined social support among AYAs with cancer and its relationship to barriers to medication adherence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Procedure<\/jats:title>\n                    <jats:p>This secondary analysis included measures of demographics, social support, and barriers to medication adherence completed by AYAs with cancer. Longitudinal path analysis was used to examine (1) predictors of social support at baseline and follow\u2010up and (2) the relationship between changes in social support and barriers to adherence at follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sixty\u2010five AYAs (ages 15\u201324 years;\n                      <jats:italic>M<\/jats:italic>\n                      age = 18.97 years) with cancer were included. Female AYAs reported baseline social support scores that were 10.09 points higher than male AYAs (\n                      <jats:italic>Est<\/jats:italic>\n                      . = 10.09,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.002). AYAs living with both parents reported higher baseline social support (\n                      <jats:italic>Est<\/jats:italic>\n                      . = 8.36,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.01) but lower social support (\n                      <jats:italic>Est<\/jats:italic>\n                      . = \u22126.54,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.04) at follow\u2010up compared to AYAs with other living arrangements. At follow\u2010up, younger age was associated with higher social support (\n                      <jats:italic>Est<\/jats:italic>\n                      . = \u22129.22,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.002). Increases in social support were associated with decreases in barriers to adherence from baseline to follow\u2010up after controlling for baseline social support, barriers to adherence, and demographic variables (\n                      <jats:italic>Est<\/jats:italic>\n                      . = \u22120.04,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Among AYAs with cancer, increases in social support over time were associated with fewer barriers to adherence, highlighting a potential area of opportunity for intervention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1545-5017.70723","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T09:48:47Z","timestamp":1790761727000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Social Support and Barriers to Medication Adherence Among Adolescents and Young Adults With Cancer"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4779-5472","authenticated-orcid":false,"given":"Katia M.","family":"Crisler","sequence":"first","affiliation":[{"name":"Division of Oncology Cancer and Blood Diseases Institute Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"},{"name":"Department of Pediatric Oncology Roswell Park Comprehensive Cancer Center, Buffalo  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4433-5924","authenticated-orcid":false,"given":"Kimberly L.","family":"Klages","sequence":"additional","affiliation":[{"name":"Division of Behavioral Medicine and Clinical Psychology Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"},{"name":"Department of Pediatrics University of Cincinnati College of Medicine  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constance A.","family":"Mara","sequence":"additional","affiliation":[{"name":"Division of Behavioral Medicine and Clinical Psychology Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"},{"name":"Department of Pediatrics University of Cincinnati College of Medicine  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8589-1804","authenticated-orcid":false,"given":"Robin E.","family":"Norris","sequence":"additional","affiliation":[{"name":"Division of Oncology Cancer and Blood Diseases Institute Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"},{"name":"Department of Pediatrics University of Cincinnati College of Medicine  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2359-473X","authenticated-orcid":false,"given":"Tyler G.","family":"Ketterl","sequence":"additional","affiliation":[{"name":"Ben Towne Center for Childhood Cancer and Blood Disorders Research Seattle Children's Hospital  Seattle Washington USA"},{"name":"Department of Pediatrics University of Washington School of Medicine  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4237-8226","authenticated-orcid":false,"given":"John P.","family":"Perentesis","sequence":"additional","affiliation":[{"name":"Division of Oncology Cancer and Blood Diseases Institute Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"},{"name":"Department of Pediatrics University of Cincinnati College of Medicine  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3150-3239","authenticated-orcid":false,"given":"Meghan E.","family":"McGrady","sequence":"additional","affiliation":[{"name":"Division of Behavioral Medicine and Clinical Psychology Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"},{"name":"Department of Pediatrics University of Cincinnati College of Medicine  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/jayao.2018.0160"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022\u20103476(83)80310\u20102"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.22019"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005147708827"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0277\u20109536(91)90150\u2010B"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/jsab100"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011\u20101635"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgph.0002918"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0169880"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/02770903.2019.1698601"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2010.08.016"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/1043454214553707"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12904\u2010024\u201001527\u2010y"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejon.2019.09.008"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejon.2015.08.007"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010023\u201007863\u20108"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.30186"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/jsm030"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/jsu102"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/10705511.2016.1269606"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.6282"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/geronb\/gbv061"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0285373"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijnss.2018.11.008"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/09638237.2025.2512304"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.122.009342"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/09540121.2020.1739206"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1545-5017.70723","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/1545-5017.70723","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1545-5017.70723","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T09:48:48Z","timestamp":1790761728000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/1545-5017.70723"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,30]]},"references-count":27,"alternative-id":["10.1002\/1545-5017.70723"],"URL":"https:\/\/doi.org\/10.1002\/1545-5017.70723","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,30]]},"assertion":[{"value":"2026-06-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70723"}}