{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:53:00Z","timestamp":1791208380223,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood & Cancer"],"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Reduced bone mineral density (BMD) has been reported in survivors of childhood and young adult acute lymphoblastic leukaemia (ALL); however, data from cohorts treated with contemporary protocols and including matched controls remain limited.<\/jats:p>\n <\/jats:sec>\n \n Procedure<\/jats:title>\n In this population\u2010based matched cross\u2010sectional study, we used data from the Danish ALL\u2010STAR cohort, comprising ALL survivors diagnosed between 2008 and 2019 at 1\u201345 years of age and treated according to the NOPHO ALL2008 protocol, and age\u2010 and sex\u2010frequency matched controls. Participants were evaluated at least 1 year after completion of therapy and underwent dual\u2010energy x\u2010ray absorptiometry between 2019 and 2024. BMD was adjusted for sex, age and height and compared with that of matched controls.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n The study included 298 ALL survivors and 346 matched controls. Median age at follow\u2010up was 14.1 years, and the median time since diagnosis was 6.9 years. The greatest deficits in adjusted BMD were observed at hip sites, particularly among high\u2010risk\u2013treated survivors, with adjusted mean values of 91.2% (95% CI 88.2\u201394.4) at the femoral neck, 90.1% (95% CI 86.9\u201393.3) at the total hip, and 90.3% (95% CI 87.0\u201393.7) at the trochanter. Increasing time since diagnosis was associated with partial normalisation of BMD relative to controls in the standard\u2010 and intermediate\u2010risk groups, a pattern not observed among high\u2010risk\u2010treated survivors.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Persistent BMD deficits among survivors treated with high\u2010risk regimens, without evidence of the partial normalisation observed in the standard\u2010 and intermediate\u2010risk groups, underscore the need for long\u2010term monitoring of skeletal health in this subgroup.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/1545-5017.70727","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:05:21Z","timestamp":1791205521000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bone Mineral Density After Contemporary Treatment for Acute Lymphoblastic Leukaemia: A Matched Cross\u2010Sectional Study"],"prefix":"10.1002","author":[{"given":"Karen Schow","family":"Jensen","sequence":"first","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mette Tiedemann","family":"Skipper","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels Holtum","family":"Birkeb\u00e6k","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Aarhus University Hospital Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kjeld","family":"Schmiegelow","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Copenhagen University Hospital Rigshospitalet Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas Leth","family":"Frandsen","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Copenhagen University Hospital Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bente","family":"Langdahl","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aarhus University Aarhus Denmark"},{"name":"Department of Endocrinology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rikke Beck","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine University of Copenhagen Copenhagen Denmark"},{"name":"Department of Paediatrics and Adolescent Medicine Copenhagen University Hospital, Herlev Hospital Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asger Roer","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Department of Public Health Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"M\u00f8lgaard","sequence":"additional","affiliation":[{"name":"Department of Nutrition Exercise and Sports University of Copenhagen Copenhagen Denmark"},{"name":"Paediatric Nutrition Unit Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liv","family":"Andr\u00e9s\u2010Jensen","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Copenhagen University Hospital Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgitte Klug","family":"Albertsen","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine 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