{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T11:55:02Z","timestamp":1791374102882,"version":"4.3.1"},"reference-count":19,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Obesity is associated with chemotherapy resistance and poorer survival in pediatric high\u2010risk B\u2010lymphoblastic leukemia (B\u2010ALL). Philadelphia\u2010like (Ph\u2010like) B\u2010ALL is a high\u2010risk subset associated with poor outcomes. Our prior work linked CRLF2\u2010overexpressed Ph\u2010like B\u2010ALL with obesity. However, the prognostic impact of obesity in Ph\u2010like B\u2010ALL has not been defined. Patients with end\u2010of\u2010induction measurable residual disease (EOI MRD)\u2010positivity did poorly regardless of obesity status; however, among patients with EOI MRD\u2010negativity, obesity was associated with inferior event\u2010free survival (EFS) (3\u2010year EFS 59%\u00a0vs. 100%,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.014). These data support obesity as a poor prognostic factor in Ph\u2010like B\u2010ALL, even among patients achieving early remission.\n                  <\/jats:p>","DOI":"10.1002\/1545-5017.70748","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T11:24:22Z","timestamp":1791372262000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Obesity's Impact on Prognosis in Ph\u2010Like Acute Lymphoblastic Leukemia"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5716-4215","authenticated-orcid":false,"given":"Maiah","family":"Zarrabi","sequence":"first","affiliation":[{"name":"Children's Hospital Los Angeles Cancer and Blood Disease Institute  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Ma","sequence":"additional","affiliation":[{"name":"Children's Hospital Los Angeles Cancer and Blood Disease Institute  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueh\u2010Yun","family":"Chi","sequence":"additional","affiliation":[{"name":"Children's Hospital Los Angeles Cancer and Blood Disease Institute  Los Angeles California USA"},{"name":"Keck School of Medicine University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordana","family":"Raca","sequence":"additional","affiliation":[{"name":"Division of Human Genetics Cincinnati Children's Hospital University of Cincinnati  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2867-1298","authenticated-orcid":false,"given":"Steven D.","family":"Mittelman","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology University of California Los Angeles  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3793-6438","authenticated-orcid":false,"given":"Yong\u2010Mi","family":"Kim","sequence":"additional","affiliation":[{"name":"Children's Hospital Los Angeles Cancer and Blood Disease Institute  Los Angeles California USA"},{"name":"Keck School of Medicine University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1487-6818","authenticated-orcid":false,"given":"Etan","family":"Orgel","sequence":"additional","affiliation":[{"name":"Children's Hospital Los Angeles Cancer and Blood Disease Institute  Los Angeles California USA"},{"name":"Keck School of Medicine University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1400972"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102017\u201006\u2010743252"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jncimonographs\/lgz020"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102014\u201008\u2010595389"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.115.124586"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.52.6962"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021011106"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmoldx.2018.06.009"},{"key":"e_1_2_10_10_1","first-page":"1","article-title":"CDC Growth Charts: United States\"","author":"Kuczmarski R. 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