{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T14:45:54Z","timestamp":1791816354934,"version":"4.3.4"},"reference-count":45,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp;amp; Cancer"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Infant bone and soft tissue neoplasms present distinct clinical challenges and lack large\u2010scale data to inform treatment decisions. This study aims to characterize bone and soft tissue neoplasms in infants in Canada and to compare their outcomes with those of older pediatric patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective population\u2010based cohort study using the Cancer in Young People in Canada (CYP\u2010C) database, including all children &lt;10 years with extracranial bone and soft tissue neoplasms diagnosed between 2001 and 2020. Kaplan\u2013Meier and Cox regression analyses compared treatment\u2010related mortality (TRM), cumulative incidence of relapse (CIR), event\u2010free survival (EFS), and overall survival (OS) between infants (&lt;1 year) and older children (1 to \u226410 years).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 1102 children with bone and soft tissue neoplasms were included, including 146 infants (13.2%). The most common infant tumor subtypes were fibrosarcoma (28.8%), malignant rhabdoid tumors (26.7%), rhabdomyosarcoma (25.3%), clear cell and undifferentiated sarcoma (8.9%), and Ewing sarcoma (4.1%). Compared with older children, infants had a higher risk of TRM (4.8% vs. 1.5%; HR (hazard ratio) 4.03;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.003), inferior 1\u2010year (63.7% vs. 81.5%;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) and 5\u2010year OS (56.9% vs. 62.0%;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), and a lower but non\u2010significant 5\u2010year CIR (26.3% vs. 38.4%;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.19). After adjustment for tumor subtype and metastatic status, infancy remained independently associated with poorer OS (adjusted HR 1.61, 95% confidence interval [CI] 1.13\u20132.31;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.009).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Despite no increased risk of relapse, infants with bone and soft tissue neoplasms have significantly poorer survival than older children, primarily due to a substantially higher risk of TRM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1545-5017.70753","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T13:56:01Z","timestamp":1791813361000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bone and Soft Tissue Neoplasms in Infants Versus Older Children: A Report From the Cancer in Young People in Canada Program"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6175-7547","authenticated-orcid":false,"given":"Samuel","family":"Sassine","sequence":"first","affiliation":[{"name":"Division of Pediatric Hematology\u2010Oncology Department of Pediatrics Charles\u2010Bruneau Cancer Center CHU Sainte\u2010Justine  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0820-6276","authenticated-orcid":false,"given":"Hallie","family":"Coltin","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\u2010Oncology Department of Pediatrics Charles\u2010Bruneau Cancer Center CHU Sainte\u2010Justine  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1922-4381","authenticated-orcid":false,"given":"Maria","family":"Kondyli","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\u2010Oncology Department of Pediatrics Charles\u2010Bruneau Cancer Center CHU Sainte\u2010Justine  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monia","family":"Marzouki","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\u2010Oncology Department of Pediatrics Charles\u2010Bruneau Cancer Center CHU Sainte\u2010Justine  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4243-6916","authenticated-orcid":false,"given":"Nicolas","family":"Prud'homme","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\u2010Oncology Department of Pediatrics Charles\u2010Bruneau Cancer Center CHU Sainte\u2010Justine  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nida","family":"Usmani","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\u2010Oncology Department of Pediatrics Charles\u2010Bruneau Cancer Center CHU Sainte\u2010Justine  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3315-4383","authenticated-orcid":false,"given":"Rebecca J.","family":"Deyell","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology\/Cellular Therapy B.C. 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Hematology\u2010Oncology McMaster Children's Hospital  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9829-7089","authenticated-orcid":false,"given":"Sarah","family":"McKillop","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\u2010Oncology Stollery Children's Hospital  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2973-4687","authenticated-orcid":false,"given":"Roona","family":"Sinha","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\u2010Oncology Jim Pattison Children's Hospital  Saskatoon Saskatchewan Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0951-3091","authenticated-orcid":false,"given":"Lillian","family":"Sung","sequence":"additional","affiliation":[{"name":"Division of Paediatric Haematology\/Oncology The Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Vezina","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\u2010Oncology Montreal Children's Hospital  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3447-0743","authenticated-orcid":false,"given":"Laura","family":"Wheaton","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\u2010Oncology Kingston Health Sciences Centre  Kingston Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra P.","family":"Zorzi","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\u2010Oncology Children's Hospital London Health Sciences Centre  London Ontario 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