{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T09:50:43Z","timestamp":1791798643749,"version":"4.3.4"},"reference-count":31,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp;amp; Cancer"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Retinoblastoma is the most common primary intraocular neoplasm in children. Use of radiotherapy has decreased due to the incidence of second malignant neoplasms (SMNs). In our study, photon (\n                    <jats:italic>n<\/jats:italic>\n                    = 42) and proton (\n                    <jats:italic>n<\/jats:italic>\n                    = 66) radiotherapy cohorts had median follow\u2010up of 28.7 and 18.2 years, respectively. The majority of patients (74%) had bilateral disease at diagnosis. Proton radiotherapy is associated with significantly lower cumulative incidence of in\u2010field SMNs (0%\u00a0vs. 11.1% at 15 years,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.005), with three additional cases occurring &gt; 20 years after photon radiotherapy. These findings suggest that when radiotherapy is indicated for patients with bilateral retinoblastoma, proton radiotherapy should be considered when feasible.\n                  <\/jats:p>","DOI":"10.1002\/1545-5017.70754","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T09:36:58Z","timestamp":1791797818000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Proton Radiotherapy Decreases Incidence of Radiation\u2010Induced Second Malignant Neoplasms Compared to Photon Radiotherapy in Patients With Retinoblastoma"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5559-8554","authenticated-orcid":false,"given":"Sayeh","family":"Fattahi","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Mass General Brigham Cancer Institute Harvard Medical School  Boston Massachusetts USA"},{"name":"Department of Radiation Oncology, Dana\u2010Farber Cancer Institute, Boston Children's Hospital Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1390-7221","authenticated-orcid":false,"given":"Daniel G.","family":"Packard","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6157-5489","authenticated-orcid":false,"given":"Beow Y.","family":"Yeap","sequence":"additional","affiliation":[{"name":"Biostatistics\/Medicine, Massachusetts General Hospital Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roshan V.","family":"Sethi","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Mass General Brigham Cancer Institute Harvard Medical School  Boston Massachusetts 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