{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T13:41:59Z","timestamp":1792676519843,"version":"4.5.0"},"reference-count":16,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Intrathecal methotrexate (MTX) remains a critical component in multiagent chemotherapy regimens for acute lymphoblastic leukemia (ALL). However, MTX\u2010induced neurotoxicity (MIN) can cause significant morbidity. Aminophylline can be a treatment for MIN, mitigating neurotoxicity, but its use has been restricted to case reports and small patient series. In this report, we present treatment outcomes of seven patients who developed MIN and received aminophylline. The median time\u2010to\u2010improvement after aminophylline was 9\u00a0h, and the median time to full resolution of symptoms was 36\u00a0h. All patients developed full symptom resolution, advocating aminophylline as treatment of MIN in patients with ALL.<\/jats:p>","DOI":"10.1002\/1545-5017.70772","type":"journal-article","created":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T13:13:49Z","timestamp":1792674829000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Aminophylline Administration for Treatment of Methotrexate\u2010Induced Neurotoxicity in Pediatric Cancer Patients: A Single\u2010Center Case Series"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6180-0170","authenticated-orcid":false,"given":"Ryan","family":"Guerrettaz","sequence":"first","affiliation":[{"name":"Department of Pediatric Hematology\/Oncology\/BMT Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Bodenbach","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Tennessee Health Science Center Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Watson","sequence":"additional","affiliation":[{"name":"Children's Hospital of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arica","family":"Christensen","sequence":"additional","affiliation":[{"name":"Children's Hospital of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Burke","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\/Oncology\/BMT Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,22]]},"reference":[{"issue":"9","key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1200\/JCO.2013.53.0808","article-title":"Methotrexate\u2010Induced Neurotoxicity and Leukoencephalopathy in Childhood Acute Lymphoblastic Leukemia","volume":"32","author":"Bhojwani D.","year":"2014","journal-title":"Journal of Clinical Oncology"},{"issue":"4","key":"e_1_2_6_3_1","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1002\/pbc.25850","article-title":"Rechallenging With Intrathecal Methotrexate After Developing Subacute Neurotoxicity in Children with Hematologic Malignancies","volume":"63","author":"Badke C.","year":"2016","journal-title":"Pediatric Blood & Cancer"},{"issue":"1","key":"e_1_2_6_4_1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.pediatrneurol.2008.09.005","article-title":"Folate Homeostasis in Cerebrospinal Fluid During Therapy for Acute Lymphoblastic Leukemia","volume":"40","author":"Cole P. 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