{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T06:15:14Z","timestamp":1773382514575,"version":"3.50.1"},"reference-count":56,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Hemodialysis (HD) is the most widely utilized dialysis method globally. However, hemodiafiltration (HDF) is garnering significant interest. This study aimed to evaluate mortality rates in patients with end\u2010stage kidney disease (ESKD) using HDF in comparison to high\u2010flux HD (hf\u2010HD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The Cochrane, Embase, Epistemonikos, and PubMed databases were searched until October 30, 2024.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Seven studies met the inclusion criteria. Compared to the hf\u2010HD group, the risk ratio (RR) for all\u2010cause mortality with HDF was 0.78 (95% CI 0.68\u20130.89). Likewise, the risks of cardiovascular death and infection\u2010related death were lower in the HDF group. Subgroup analysis indicated a reduction in all\u2010cause mortality among nondiabetic patients in the HDF group. ESKD patients without preexisting cardiovascular disease (CVD) exhibited an RR of 0.61 (95% CI 0.45\u20130.77) for all\u2010cause deaths.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The use of HDF in comparison to hf\u2010HD reduced the risk of death in nondiabetic patients and those without preexisting CVD. Given the high cost associated with HDF, further studies are necessary to confirm these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1744-9987.70101","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T10:26:27Z","timestamp":1766139987000},"page":"176-187","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hemodiafiltration Improves Survival Among Nondiabetics, Individuals Without Cardiovascular Disease, and the Elderly: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4730-0946","authenticated-orcid":false,"given":"Paulo Roberto","family":"Bignardi","sequence":"first","affiliation":[{"name":"School of Medicine, Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1  Londrina Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larissa Carolina","family":"Rosin","sequence":"additional","affiliation":[{"name":"School of Medicine, Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1  Londrina Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinicius Daher Alvares","family":"Delfino","sequence":"additional","affiliation":[{"name":"School of Medicine, Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1  Londrina Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(16)32064\u20105"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.KISU.2021.11.003"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000514550"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-13-8871-2_1"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.34067\/KID.0000000000000145"},{"issue":"1","key":"e_1_2_10_7_1","first-page":"31","article-title":"Effects of High\u2010Flux Versus Low\u2010Flux Membranes on Pulmonary Function Tests in Hemodialysis Patients","volume":"12","author":"Momeni A.","year":"2013","journal-title":"Tanaffos"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/KI.1997.274"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525\u2010139X.2010.00786.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2008060590"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000142528"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfy035"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa2304820"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2012080875"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/NDT\/GFX277"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/hdi.13136"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_10_18_1","volume-title":"Cochrane Training","author":"Higgins J. P.","year":"2019"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfs407"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2017.01.013"},{"issue":"1","key":"e_1_2_10_21_1","first-page":"26","article-title":"Prospective Randomized Cross\u2010Over Long\u2010Term Comparison of Online Haemodiafiltration and Ultrapure High\u2010Flux Haemodialysis","volume":"12","author":"Schiffl H.","year":"2007","journal-title":"European Journal of Medical Research"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.17151120"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.KRCP.2013.06.002"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2024.07.014"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.12631117"},{"key":"e_1_2_10_26_1","volume-title":"StatPearls [Internet]","author":"Murdeshwar H. N.","year":"2025"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820070403"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1159\/000520466"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201059794\u20107"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(24)01859\u20102"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2021091257"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1046\/J.1523\u20101755.2002.00504.X"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1053\/J.ACKD.2019.01.004"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V991689"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins12070439"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40620\u2010015\u20100195\u2010z"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/NDT\/GFAD063C_6158"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/TOXINS12050300"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41598\u2010018\u201037195\u20101"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/NDT\/GFV038"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6651367"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/IJMS21010263"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.5551\/JAT.RV22006"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.4103\/0971\u20104065.202405"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/IJMS21051835"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.2459\/JCM.0b013e328333645a"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/S12933\u2010023\u201001867\u20108\/FIGURES\/3"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/NDT\/GFAC083.014"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.17267\/2675\u2010021Xevidence.2023.e4060"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.01381005"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/SJ.KI.5002343"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.3400\/AVD.RA.17\u201000051"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.050686"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255\u2010017\u20101543\u20109"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.3390\/JCM13041110"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfad136"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1093\/CKJ\/SFAE147"}],"container-title":["Therapeutic Apheresis and Dialysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1744-9987.70101","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/1744-9987.70101","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1744-9987.70101","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:01:43Z","timestamp":1773360103000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/1744-9987.70101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,19]]},"references-count":56,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/1744-9987.70101"],"URL":"https:\/\/doi.org\/10.1002\/1744-9987.70101","archive":["Portico"],"relation":{},"ISSN":["1744-9979","1744-9987"],"issn-type":[{"value":"1744-9979","type":"print"},{"value":"1744-9987","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,19]]},"assertion":[{"value":"2025-05-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}