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However, its effect on vision and retinal microcirculation in stroke patients has never been reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Between November 2023 and June 2024, five patients underwent DELP treatment as a routine adjuvant therapy for AIS. Detailed ophthalmological examinations, including best corrected visual acuity (BCVA) and optical coherence tomography angiography (OCTA), were performed on them one day prior to and 1\u20133\u2009days following the DELP treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the ten eyes examined, six had diabetic retinopathy (DR), two had dry age\u2010related macular degeneration (dAMD), one had idiopathic epiretinal membrane (iERM), and one was normal. Surprisingly, after DELP treatment, the BCVA improved by 0.2LogMAR in six eyes, 0.1LogMAR in three eyes, and remained unchanged in one eye. The vessel density (VD) in the fovea increased in six eyes, remained unchanged in three eyes, and decreased in one eye. The non\u2010perfusion area (NPA) in the superficial capillary plexus (SCP) decreased in six eyes, remained unchanged in two eyes, and increased in two eyes. The NPA in the deep capillary plexus (DCP) decreased in eight eyes and remained unchanged in two eyes. A small amount of bleeding occurred in Patient 3's right eye, and no other adverse events were observed post\u2010treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this case series, the DELP treatment showed a potentially significant therapeutic effect on the BCVA and retinal microcirculation in AIS patients with good safety and provided a rationale for further investigation. At the same time, this treatment may provide an effective option for the treatment of eye diseases such as DR, iERM, and AMD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1744-9987.70102","type":"journal-article","created":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T00:10:36Z","timestamp":1765843836000},"page":"168-175","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>DELP<\/scp>\n                    Treatment on Vision and Retinal Microcirculation in Patients With Acute Ischemic Stroke: Report of Five Cases and Literature Review"],"prefix":"10.1002","volume":"30","author":[{"given":"Ning","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurology Shanghai Jing'an District Shibei Hospital  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronghua","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurological Rehabilitation, Shanghai Disabled Persons' Federation Key Laboratory of Intelligent Rehabilitation Assistive Devices and Technologies, Yangzhi Rehabilitation Hospital, School of Medicine Tongji University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"You","sequence":"additional","affiliation":[{"name":"Department of Neurology Shanghai Jing'an District Shibei Hospital  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feiping","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Shanghai Jing'an District Shibei Hospital  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingjun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology Shanghai Jing'an District Shibei Hospital  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiwen","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Neurology Shanghai Jing'an District Shibei Hospital  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuting","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Neurology Shanghai Jing'an District Shibei Hospital  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danmei","family":"Lan","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurological Rehabilitation, Shanghai Disabled Persons' Federation Key Laboratory of Intelligent Rehabilitation Assistive Devices and Technologies, Yangzhi Rehabilitation Hospital, School of Medicine Tongji University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7199-2578","authenticated-orcid":false,"given":"Lingjing","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurological Rehabilitation, Shanghai Disabled Persons' Federation Key Laboratory of Intelligent Rehabilitation Assistive Devices and Technologies, Yangzhi Rehabilitation Hospital, School of Medicine Tongji University  Shanghai China"},{"name":"Collaborative Innovation Center for Brain Science Tongji University  Shanghai China"},{"name":"Clinical Center for Brain and Spinal Cord Research Tongji University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5232-4048","authenticated-orcid":false,"given":"Junhui","family":"She","sequence":"additional","affiliation":[{"name":"Department of Neurology Shanghai Jing'an District Shibei Hospital  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,15]]},"reference":[{"issue":"3","key":"e_1_2_12_2_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0213035","article-title":"High Incidence and Prevalence of Visual Problems After Acute Stroke: An Epidemiology Study With Implications for Service Delivery","volume":"14","author":"Lewin A. 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