{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T06:15:46Z","timestamp":1773382546006,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T00:00:00Z","timestamp":1766880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T00:00:00Z","timestamp":1766880000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Cognitive impairment and exercise intolerance are common in dialysis patients. Cerebral perfusion and oxygenation play a major role in both cognitive function and exercise execution; HD session per se aggravates cerebral ischemia in this population. This study aimed to compare cerebral oxygenation and perfusion at rest and in mild physical stress between HD and PD patients, as well as controls without CKD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Eighty\u2010one participants (27 HD, 27 PD and 27 controls, matched for age, sex) underwent a 3\u2010min intermittent\u2010handgrip\u2010exercise at 35% of their maximal\u2010voluntary\u2010contraction (MVC). During exercise, cerebral oxygenation (oxyhemoglobin\u2010O\n                      <jats:sub>2<\/jats:sub>\n                      Hb, deoxyhemoglobin\u2010HHb, total\u2010hemoglobin\u2010tHb) was assessed by near\u2010infrared\u2010spectroscopy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Age, sex, dialysis\u2010vintage, and major comorbidities did not differ between groups. The average increases observed during exercise in O\n                      <jats:sub>2<\/jats:sub>\n                      Hb (cerebral oxygenation index) were significantly impaired in both dialysis modalities compared to controls, with HD patients tending to have lower levels (HD: 1.20\u2009\u00b1\u20091.03 vs. PD: 1.53\u2009\u00b1\u20090.99 vs. Controls: 2.41\u2009\u00b1\u20091.35\u2009\u03bcmol\/L,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). Similarly, the average HHb and tHb (HD: 0.57\u2009\u00b1\u20091.20 vs. PD: 1.21\u2009\u00b1\u20091.11 vs. Controls: 2.21\u2009\u00b1\u20091.50\u2009\u03bcmol\/L,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) responses were significantly lower in both dialysis groups compared to controls, with a trend toward lower levels in HD patients. As for Hb\n                      <jats:sub>diff<\/jats:sub>\n                      , a significant trend for lower values in both dialysis modalities compared to controls was observed, with no marked numerical differences between them. Blunted average responses in O\n                      <jats:sub>2<\/jats:sub>\n                      Hb, tHb, and Hb\n                      <jats:sub>diff<\/jats:sub>\n                      were associated with more impaired cognitive performance (MMSE score).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Cerebral oxygenation is blunted in both HD and PD, while HD individuals exhibit a trend toward even lower levels, potentially reflecting the cumulative cerebrovascular stress associated with intermittent dialysis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1744-9987.70113","type":"journal-article","created":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T23:32:08Z","timestamp":1766964728000},"page":"245-253","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Comparative Study of Cerebral Oxygenation During Exercise in Hemodialysis and Peritoneal Dialysis Patients"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6216-9635","authenticated-orcid":false,"given":"Marieta P.","family":"Theodorakopoulou","sequence":"first","affiliation":[{"name":"First Department of Nephrology, Hippokration Hospital Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5902-3467","authenticated-orcid":false,"given":"Konstantina","family":"Dipla","sequence":"additional","affiliation":[{"name":"Exercise Physiology &amp; Biochemistry Laboratory, Department of Sport Sciences at Serres Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danai","family":"Faitatzidou","sequence":"additional","affiliation":[{"name":"First Department of Nephrology, Hippokration Hospital Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fotini","family":"Iatridi","sequence":"additional","affiliation":[{"name":"First Department of Nephrology, Hippokration Hospital Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Areti","family":"Georgiou","sequence":"additional","affiliation":[{"name":"First Department of Nephrology, Hippokration Hospital Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7054-1422","authenticated-orcid":false,"given":"Artemios","family":"Karagiannidis","sequence":"additional","affiliation":[{"name":"First Department of Nephrology, Hippokration Hospital Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erasmia","family":"Sampani","sequence":"additional","affiliation":[{"name":"First Department of Nephrology, Hippokration Hospital Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chrysostomos","family":"Dimitriadis","sequence":"additional","affiliation":[{"name":"First Department of Nephrology, Hippokration Hospital Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aggelos","family":"Koutlas","sequence":"additional","affiliation":[{"name":"Exercise Physiology &amp; Biochemistry Laboratory, Department of Sport Sciences at Serres Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Zafeiridis","sequence":"additional","affiliation":[{"name":"Exercise Physiology &amp; Biochemistry Laboratory, Department of Sport Sciences at Serres Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9174-4018","authenticated-orcid":false,"given":"Pantelis","family":"Sarafidis","sequence":"additional","affiliation":[{"name":"First Department of Nephrology, Hippokration Hospital Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,28]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30045-3"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-020-0266-9"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2014.07.009"},{"issue":"11","key":"e_1_2_12_5_1","first-page":"gfab338","article-title":"Chronic Kidney Disease, Physical Activity and Cognitive Function in Older Adults\u2014Results From the National Health and Nutrition Examination Survey (2011\u20132014)","volume":"37","author":"Chu N. M.","year":"2021","journal-title":"Nephrology, Dialysis, Transplantation"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2004.52508.x"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000515384"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2010.08.016"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00270.2015"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.060574"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00853.2007"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.186767"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2018.01.009"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0199366"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/03913988211020017"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00438.2020"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.07920910"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/0886022X.2013.794675"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/15353702231198081"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40620-018-0494-2"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-020-01075-9"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000512263"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1159\/000514320"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2019.05.017"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2020.04.054"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1992.105"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006231-199607000-00011"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-016-9829-7"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.934420"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfad076"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0117474"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.934064"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1159\/000487092"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600478"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2017101088"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000225182.15532.40"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.5301\/jva.5000630"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5000417"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2016060704"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2021101353"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.121.17962"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612824666180702154129"},{"issue":"1","key":"e_1_2_12_43_1","first-page":"6","article-title":"Blunted Cerebral Oxygenation During Exercise in Systemic Lupus Erythematosus Patients","volume":"41","author":"Koletsos N.","year":"2023","journal-title":"Clinical and Experimental Rheumatology"}],"container-title":["Therapeutic Apheresis and Dialysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1744-9987.70113","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/1744-9987.70113","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1744-9987.70113","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:01:38Z","timestamp":1773360098000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/1744-9987.70113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,28]]},"references-count":42,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/1744-9987.70113"],"URL":"https:\/\/doi.org\/10.1002\/1744-9987.70113","archive":["Portico"],"relation":{},"ISSN":["1744-9979","1744-9987"],"issn-type":[{"value":"1744-9979","type":"print"},{"value":"1744-9987","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,28]]},"assertion":[{"value":"2025-08-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}