{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T15:35:24Z","timestamp":1787585724732,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Creatinine accumulation exacerbates outcomes in chronic kidney disease (CKD). To enhance creatinine removal and improve hemocompatibility, we developed heparin\u2010functionalized copper\u2010based metal\u2013organic frameworks (CuMOFs\u2010Hep).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      CuMOFs were heparinized via APTES bridging and characterized (XRD, SEM, FTIR, XPS, and zeta potential). Adsorption was evaluated in simulated CKD serum and was fitted with isotherm models. Whole\u2010blood samples from patients\/healthy donors were tested. Biosafety was assessed by Cu\n                      <jats:sup>2+<\/jats:sup>\n                      leaching and platelet assays.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Heparinization increased surface negative charge and raised the maximum capacity to 267.8\u2009mg\u2009g\n                      <jats:sup>\u22121<\/jats:sup>\n                      (68.7% over pristine; Langmuir\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.983). Adsorption kinetics studies indicate rapid clearance of creatinine, achieving a clearance rate of 65.9% within 30\u2009min at 37\u00b0C and reaching 75.0% within 2\u2009h. In patient blood (854.2\u2009\u03bcmol\/L), supernatant creatinine decreased to 163.2\u2009\u03bcmol\/L (80.9% removal). Cu\n                      <jats:sup>2+<\/jats:sup>\n                      leaching dropped to 0.214\u2009ppm (\u221289.9%), with reduced platelet adhesion\/activation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CuMOFs\u2010Hep enables efficient, low\u2010leaching creatinine adsorption in clinically relevant matrices, highlighting its promising potential as an efficient adsorbent for blood purification applications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1744-9987.70122","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T03:00:08Z","timestamp":1769742008000},"page":"363-370","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Adsorption of Blood Creatinine on a Heparin\u2010Functionalized Surface of Copper\u2010Based Metal\u2013Organic Frameworks"],"prefix":"10.1002","volume":"30","author":[{"given":"Zhenyu","family":"Gui","sequence":"first","affiliation":[{"name":"College of Materials and Textile Engineering Jiaxing University  Jiaxing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoda","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Materials and Textile Engineering Jiaxing University  Jiaxing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Chen","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Jiaxing University  Jiaxing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhuang","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Jiaxing University  Jiaxing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Lan","sequence":"additional","affiliation":[{"name":"College of Materials and Textile Engineering Jiaxing University  Jiaxing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,29]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-025-03978-8"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10800-025-02278-1"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-021-00284-z"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(23)00570-3"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-41642-7"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-90193-8"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-30283-x"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2023.117671"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/0886022X.2025.2528757"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2023.10.018"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiec.2024.12.047"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12221-025-01038-4"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm-21-1100"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-022-04009-w"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2025.163031"},{"key":"e_1_2_11_17_1","first-page":"11345","article-title":"Influence of Metal Identity on Light\u2010Induced Switchable Adsorption in Azobenzene\u2010Based Metal\u2013Organic Frameworks","volume":"14","author":"Han D. 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