{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:21:30Z","timestamp":1783012890492,"version":"3.54.6"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T00:00:00Z","timestamp":1775347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T00:00:00Z","timestamp":1775347200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study evaluated the effectiveness of therapeutic plasma exchange (TPE) modalities in seronegative pediatric neuroimmune disorders, focusing on acute therapy response, 6\u2010month neurological outcomes, and age\u2010stratified adverse events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective observational cohort between 2018 and 2024. Neurological outcomes were assessed at five predetermined set points during 6 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Forty\u2010six children underwent 304 TPE procedures in 49 sessions. Early favorable recovery were 84% for autoimmune\u2010encephalitis, 75% for CNS\u2010demyelinating\u2010disorders, 83.3% for Guillan\u2010Barre\u2010syndrome, 66.7% of Juvenile\u2010Myasthenia\u2010Gravis cases. Six\u2013months neurological outcome showed similar recovery rates irrespective\u2010of\u2010TPE\u2010modality used (F[4169]\u2009=\u20090.53,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.711; F[4470]\u2009=\u20090.69,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.602 for CNS and PNS disorders). Adverse events occurred in 20.1% of TPE sessions, were largely age\u2010dependent rather than disease\u2010category or modality\u2010driven, with a 0.891\u2010fold reduction in the likelihood of AE occurrence for each\u2010year increment (OR\u2009=\u20090.891, 95% CI: 0.825\u20130.962,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Centrifugal and membrane\u2010based TPE are associated with good neurological recovery in seronegative pediatric neuroimmune disorders. Patient age, rather than apheresis modality or disease subtype, has emerged as the primary determinant of the adverse event profile.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1744-9987.70140","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:14:13Z","timestamp":1775434453000},"page":"489-501","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Centrifugal Versus Membrane\u2010Based Therapeutic Plasma Exchange in Pediatric Seronegative Neuroimmune Disorders: Neurologic Outcome and Age Specific Safety Profile"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1248-8635","authenticated-orcid":false,"given":"Ebru Atike","family":"Ongun","sequence":"first","affiliation":[{"name":"Department of Pediatric Intensive Care University of Health Sciences, Antalya Training and Research Hospital  Antalya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8801-7776","authenticated-orcid":false,"given":"Sultan","family":"Ayd\u0131n","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology University of Health Sciences, Antalya Training and Research Hospital  Antalya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0120-8711","authenticated-orcid":false,"given":"Hasan Serdar","family":"K\u0131ht\u0131r","sequence":"additional","affiliation":[{"name":"Department of Pediatric Intensive Care University of Health Sciences, Antalya Training and Research Hospital  Antalya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9868-8998","authenticated-orcid":false,"given":"Erdem","family":"\u00c7ebi\u015fli","sequence":"additional","affiliation":[{"name":"Department of Pediatric Intensive Care University of Health Sciences, Antalya Training and Research Hospital  Antalya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3631-068X","authenticated-orcid":false,"given":"Muhammed Gultekin","family":"Kutluk","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology University of Health Sciences, Antalya Training and Research Hospital  Antalya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6653-5858","authenticated-orcid":false,"given":"Duygu G\u00fcner","family":"\u00d6zcany\u00fcz","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology University of Health Sciences, Antalya Training and Research Hospital  Antalya 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