{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:21:35Z","timestamp":1783012895449,"version":"3.54.6"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Therapeutic plasma exchange (TPE) is a cornerstone of therapeutic apheresis across multiple subspecialties. While international registries have described global practice, nationwide data from Thailand are lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a 10\u2010year retrospective analysis of all TPE admissions reimbursed under Thailand's Universal Health Coverage scheme (2014\u20132023). Cases were identified using ICD\u20109 code 997.1. Demographics, clinical indications, complications, outcomes, and costs were extracted from discharge records. Indications were categorized according to the 2023 American Society for Apheresis (ASFA) guidelines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 5884 admissions were identified. The mean age was 46.4\u2009\u00b1\u200920.6\u2009years, 58.0% were male, and 13.0% were pediatric. TPE Utilization increased from the mid\u2010200s in 2014 to nearly 900 admissions in 2023. Neurological (28.9%) and nephrological (24.4%) disorders were the leading subspecialties. Systemic lupus erythematosus (12.4%), septic shock (12.1%), and acute inflammatory demyelinating polyradiculoneuropathy (9.1%) were the most frequent disease\u2010specific indications. Nearly three\u2010quarters of procedures were guideline\u2010supported (Category I: 28.6%, Category II: 31.7%), while Category III use was 28.1% in our cohort. In\u2010hospital mortality was 51.6% overall, driven largely by septic shock and acute liver failure, whereas survival exceeded 70% in autoimmune neurologic diseases and transplant recipients. Complications included bleeding (25.5%), transfusion requirements (69.0%), and hypocalcemia (9.7%). The actual cost per admission ranged USD 4000\u201312000, while reimbursement covered USD 2000\u20137000.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This first nationwide analysis of TPE in Thailand highlights increasing utilization, high\u2010cost burden, and important differences from global practice. Strengthening registries, refining coding systems, and developing region\u2010specific guidelines will be critical to optimize outcomes and sustainability.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1744-9987.70148","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T05:06:11Z","timestamp":1776834371000},"page":"569-584","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Therapeutic Plasma Exchange in Thailand: A 10\u2010Year Retrospective Analysis"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2071-1996","authenticated-orcid":false,"given":"Kornchanok","family":"Vareesangthip","sequence":"first","affiliation":[{"name":"Renal Division, Department of Medicine, Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok 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Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parichart","family":"Permpikul","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine, Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adisorn","family":"Lumpaopong","sequence":"additional","affiliation":[{"name":"Division of Pediatric Nephrology, Department of Pediatrics Phramongkutklao Hospital and College of Medicine  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kriengsak","family":"Vareesangthip","sequence":"additional","affiliation":[{"name":"Renal Division, Department of Medicine, Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok 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