{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T14:16:58Z","timestamp":1788445018442,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T00:00:00Z","timestamp":1778976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T00:00:00Z","timestamp":1778976000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Uremic toxins are a growing area of research in nephrology, with significant implications in the progression and treatment of chronic kidney disease (CKD) and the management of end\u2010stage kidney disease (ESKD). This bibliometric analysis aims to evaluate the global research trends, key contributors, and the impact of publications in the field of uremic toxins from 1991 to 2024.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The data were retrieved from the Science Citation Index Expanded (SCI\u2010EXPANDED) database. The study analyzed 2210 articles using various bibliometric indicators, including total publications (\n                      <jats:italic>TP<\/jats:italic>\n                      ), average number of citations per publication (\n                      <jats:italic>CPP<\/jats:italic>\n                      <jats:sub>2024<\/jats:sub>\n                      ), and the\n                      <jats:italic>Y<\/jats:italic>\n                      \u2010index for author contributions. Publication trends were examined across countries, institutions, and authors. The analysis included document types, languages, Web of Science categories, and journals.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The study revealed a steady increase in uremic toxin research publications. Japan, the USA, and China remained the most productive countries, with Japan maintaining the highest output, while Belgium achieved the highest citation impact. Citations of uremic toxin\u2010related research peaked 2\u2009years following publication and plateaued after approximately 6\u2009years. The research foci evolved, with CKD, ESKD, indoxyl sulfate, protein\u2010bound solutes, and gut microbiota gaining prominence. Studies on oxidative stress, inflammation, metabolomics, and advanced adsorption\u2010based toxin removal strategies increased markedly. International collaboration and interdisciplinary integration across nephrology, microbiology, and biochemistry correlated with higher citation performance and research visibility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This bibliometric study provides an in\u2010depth analysis of uremic toxin research trends, identifies major contributors, and suggests future research priorities. The findings can inform future research directions, guide funding allocation, and strengthen global collaborative efforts towards improved management of toxin\u2010related kidney disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1744-9987.70154","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T03:40:12Z","timestamp":1779075612000},"page":"627-640","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Bibliometric Analysis of Publications in Uremic Toxins From 1991 to 2024"],"prefix":"10.1002","volume":"30","author":[{"given":"Yuh\u2010Shan","family":"Ho","sequence":"first","affiliation":[{"name":"CT HO Trend  Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0960-2644","authenticated-orcid":false,"given":"Karim M.","family":"Soliman","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Nephrology Medical University of South Carolina  Charleston South Carolina USA"},{"name":"Medical Services, Ralph H. Johnson VA Medical Center  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9954-9711","authenticated-orcid":false,"given":"Wisit","family":"Cheungpasitporn","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1765-6159","authenticated-orcid":false,"given":"Wannasit","family":"Wathanavasin","sequence":"additional","affiliation":[{"name":"Nephrology Unit, Department of Medicine, Charoenkrung Pracharak Hospital, Bangkok Metropolitan Administration  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Daoud","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Nephrology Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed I.","family":"Kamal","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Nephrology Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bal\u00e1zs","family":"Szamosfalvi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Nephrology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3346-7040","authenticated-orcid":false,"given":"Tibor","family":"F\u00fcl\u00f6p","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Nephrology Medical University of South Carolina  Charleston South Carolina USA"},{"name":"Medical Services, Ralph H. 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