{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T12:04:36Z","timestamp":1781006676944,"version":"3.54.1"},"reference-count":14,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>This study investigated the safety and efficacy of single\u2010needle Rheocarna therapy for chronic limb\u2010threatening ischemia (CLTI) with wounds.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Six patients with CLTI involving ulcers unresponsive to revascularization underwent single\u2010needle Rheocarna treatment. Changes in mean low\u2010density lipoprotein cholesterol (LDL\u2010C), fibrinogen, C\u2010reactive protein (CRP), white blood cell (WBC) count, platelet count, blood flow, and wound improvement were compared between treatment initiation and completion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The treatment never required discontinuation due to in\u2010circuit coagulation or hypotension, and its safety was confirmed. After 10 treatment sessions, LDL\u2010C and fibrinogen removal rates were 24.3% and 24.4%, respectively. Platelet, WBC, and CRP values did not change significantly over time. Blood flow increased during treatment and posttreatment. All patients experienced wound improvement and favorable clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Single\u2010needle Rheocarna therapy is effective for wound healing in CLTI. If this method applies to nondialysis patients without arteriovenous fistulas, indications for Rheocarna therapy will likely expand.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1744-9987.70161","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T11:40:25Z","timestamp":1781005225000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Experience With Performing Rheocarna Therapy via the Single\u2010Needle Method for Treatment of Chronic Limb\u2010Threatening Ischemia"],"prefix":"10.1002","author":[{"given":"Yasutaka","family":"Yamauchi","sequence":"first","affiliation":[{"name":"Cardiovascular Center, Takatsu General Hospital  Kawasaki Kanagawa Japan"},{"name":"Department of Cardiology Tokyo Heart Center, Osaki Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rie","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Clinical Engineer Takatsu General Hospital  Kawasaki Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reona","family":"Kawahira","sequence":"additional","affiliation":[{"name":"Department of Clinical Engineer Takatsu General Hospital  Kawasaki Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shingo","family":"Nabeta","sequence":"additional","affiliation":[{"name":"Department of Clinical Engineer Takatsu General Hospital  Kawasaki Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kouhei","family":"Naoi","sequence":"additional","affiliation":[{"name":"Department of Clinical Engineer Takatsu General Hospital  Kawasaki Kanagawa Japan"},{"name":"Department of Clinical Engineer Tokyo Heart Center, Osaki Hospital  Tokyo 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