{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:21:27Z","timestamp":1783012887095,"version":"3.54.6"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic limb\u2010threatening ischemia (CLTI) is a severe form of lower\u2010extremity artery disease characterized by distal lesions and microcirculatory impairment, limiting revascularization efficacy. Rheocarna is a direct hemoperfusion low\u2010density lipoprotein (LDL) adsorption device with potential rheological and anti\u2010inflammatory benefits. The real\u2010world effectiveness of Rheocarna in patients with advanced CLTI undergoing hemodialysis (HD) remains unclear. This study evaluated clinical outcomes of Rheocarna therapy in patients with CLTI undergoing HD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively reviewed 31 patients undergoing HD (mean [\u00b1SD] age 67\u2009\u00b1\u200911\u2009years) with CLTI treated with Rheocarna at a single center. Primary outcomes were ulcer healing at 6\u2009months and amputation\u2010free survival (AFS) at 1\u2009year, with baseline characteristics compared between healed and non\u2010healed groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At 6\u2009months, the ulcer healing, major amputation, and mortality rates were 25.8%, 35.5%, and 22.6%, respectively. The 1\u2010year AFS rate was 40%. The mean ankle\u2013brachial index significantly improved from 1.00\u2009\u00b1\u20090.17 to 1.07\u2009\u00b1\u20090.15 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.041).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Rheocarna may support wound healing and limb salvage in patients with CLTI undergoing HD; however, its clinical effectiveness appears limited in advanced disease stages.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1744-9987.70164","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:36:25Z","timestamp":1782174985000},"page":"476-481","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effectiveness of a Novel Low\u2010Density Lipoprotein Apheresis Device Rheocarna in Patients Undergoing Hemodialysis With Chronic Limb\u2010Threatening Ischemia: A Single\u2010Center Retrospective Study"],"prefix":"10.1002","volume":"30","author":[{"given":"Kunihiro","family":"Ishioka","sequence":"first","affiliation":[{"name":"Department of Nephrology, Kidney Disease and Transplant Center Shonan Kamakura General Hospital  Kamakura Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayasu","family":"Ohtake","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Kidney Disease and Transplant Center Shonan Kamakura General Hospital  Kamakura Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Ohmori","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Kidney Disease and Transplant Center Shonan Kamakura General Hospital  Kamakura Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chika","family":"Shibuya","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Kidney Disease and Transplant Center Shonan Kamakura General Hospital  Kamakura Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoki","family":"Tsukahara","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Kidney Disease and Transplant Center Shonan Kamakura General Hospital  Kamakura Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mizuki","family":"Yamano","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Kidney Disease and Transplant Center Shonan Kamakura General Hospital  Kamakura Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Mochida","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Kidney Disease and Transplant Center Shonan Kamakura General Hospital  Kamakura Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Machiko","family":"Oka","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Kidney Disease and Transplant Center Shonan Kamakura General Hospital  Kamakura Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoko","family":"Maesato","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Kidney Disease and Transplant Center Shonan Kamakura General Hospital  Kamakura Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Tsukamoto","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Kidney Disease and Transplant Center Shonan Kamakura General Hospital  Kamakura Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidekazu","family":"Moriya","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Kidney Disease and Transplant Center Shonan Kamakura General Hospital  Kamakura Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumi","family":"Hidaka","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Kidney Disease and Transplant Center Shonan Kamakura General Hospital  Kamakura Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuzo","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Kidney Disease and Transplant Center Shonan Kamakura General Hospital  Kamakura Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2019.02.016"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.5551\/jat.65843"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2024.12.128"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3400\/avd.ra.17-00006"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.5551\/jat.64639"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.5551\/jat.RV17033"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-007-0003-8"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/1744-9987.12450"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-24-0830"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/1744-9987.13915"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14082589"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.117.005531"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.5551\/jat.35915"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.5551\/jat.42648"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2012.07.017"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.25676"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2014.09.007"}],"container-title":["Therapeutic Apheresis and Dialysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1744-9987.70164","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/1744-9987.70164","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1744-9987.70164","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T16:47:13Z","timestamp":1783010833000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/1744-9987.70164"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,22]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/1744-9987.70164"],"URL":"https:\/\/doi.org\/10.1002\/1744-9987.70164","archive":["Portico"],"relation":{},"ISSN":["1744-9979","1744-9987"],"issn-type":[{"value":"1744-9979","type":"print"},{"value":"1744-9987","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,22]]},"assertion":[{"value":"2026-01-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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