{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T06:15:36Z","timestamp":1783491336962,"version":"3.55.0"},"reference-count":11,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To characterize early weight\u2010indexed vasoactive\u2010inotropic score (VIS) trajectories after polymyxin B hemoperfusion (PMX\u2010HP) in septic shock and examine association with 28\u2010day mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively studied 64 adult intensive care unit patients treated with PMX\u2010HP from July 2013 to December 2019. VIS was calculated after body\u2010weight indexing. T1 was before the first session, T2 after the final session, and T3 24\u2009h later. Immediate sustained response required T2 reduction without T3 rebound; delayed response required later reduction; adverse trajectory included no response, rebound, or death before T3.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010nine patients (45.3%) had immediate sustained response, two (3.1%) delayed response, and 33 (51.6%) adverse trajectory. Twelve died before planned T3. Among 60 verified timestamps, median shock\u2010to\u2010treatment interval was 17.3\u2009h (interquartile range, 6.6\u201327.7); median session duration was 2.0\u2009h (interquartile range, 2.0\u20132.3). Twenty\u2010eight\u2010day mortality was 31.0%, 0.0%, and 63.6%, respectively. Adverse trajectory had higher unadjusted odds of 28\u2010day mortality than immediate sustained response (odds ratio, 3.89; 95% confidence interval, 1.35\u201311.22). In an age\u2010 and Acute Physiology and Chronic Health Evaluation II\u2010adjusted model excluding delayed response, the adjusted odds ratio was 4.17 (95% confidence interval, 1.35\u201312.86;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.013). Landmark sensitivity analysis was directionally consistent but imprecise.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Failure to achieve sustained early reduction in weight\u2010indexed vasoactive support, rebound, or death before reassessment identified an adverse early clinical course. Findings support cautious risk stratification, not causal evidence of treatment efficacy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1744-9987.70179","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:34:27Z","timestamp":1783488867000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Early Vasoactive\u2010Inotropic Response Trajectories After Polymyxin B Hemoperfusion in Septic Shock: A Single\u2010Center Retrospective Cohort Study"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-8179-0486","authenticated-orcid":false,"given":"Wei\u2010Hung","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine MacKay Memorial Hospital  Taipei Taiwan"},{"name":"MacKay Medical College  New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuan\u2010Pen","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine MacKay Memorial Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Kuo","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine MacKay Memorial Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6062-6178","authenticated-orcid":false,"given":"Chung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Chest Medicine Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation  New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,7]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0287"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134\u2010021\u201006506\u2010y"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(18)30696\u20102"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.14618"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134\u2010018\u20105463\u20107"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20102600(26)00047\u20100"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10030495"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2023.1126888"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(07)61602\u2010X"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/life15081317"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines13122904"}],"container-title":["Therapeutic Apheresis and Dialysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1744-9987.70179","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/1744-9987.70179","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1744-9987.70179","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:34:27Z","timestamp":1783488867000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/1744-9987.70179"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,7]]},"references-count":11,"alternative-id":["10.1002\/1744-9987.70179"],"URL":"https:\/\/doi.org\/10.1002\/1744-9987.70179","archive":["Portico"],"relation":{},"ISSN":["1744-9979","1744-9987"],"issn-type":[{"value":"1744-9979","type":"print"},{"value":"1744-9987","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,7]]},"assertion":[{"value":"2026-05-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"1744-9987.70179"}}