{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T04:15:15Z","timestamp":1783484115374,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Serum phosphorus (P) levels have been associated with QT interval prolongation in patients undergoing hemodialysis. However, it is unclear whether this association exists in patients undergoing peritoneal dialysis (PD) in the absence of acute electrolyte fluctuations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross\u2010sectional study was conducted among adult patients on maintenance PD who were enrolled in the Japanese Society for Dialysis Therapy and Renal Data Registry in 2020. After assessing patient characteristics, a linear regression analysis was performed with serum calcium (Ca) and P levels as exposures and rate\u2010corrected QT (QTc) interval as the outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>This study included 3566 patients with a mean QTc of 449.1\u2009\u00b1\u200934.5. Of these, 251 (7.0%) had QT interval prolongation (QTc\u2009&gt;\u2009500\u2009msec). Univariate analysis showed a statistically significant association between lower corrected Ca and longer QTc interval, as well as higher P and longer QTc. Only the association between higher P and longer QTc remained statistically significant in multivariate analysis. Restricted cubic spline showed that QTc tended to increase with lower corrected Ca, whereas QTc time tended to increase with higher phosphate levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>An association between hypocalcemia and QT interval prolongation was confirmed in patients undergoing PD, similar to findings in hemodialysis. However, unlike in hemodialysis, an association between serum P levels and QT interval was found only in cases of hyperphosphatemia and not in the context of hypophosphatemia and QT interval prolongation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1744-9987.70184","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T03:36:36Z","timestamp":1783481796000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of Serum Phosphorus Levels With\n                    <scp>QT<\/scp>\n                    Prolongation in Patients With End\u2010Stage Kidney Disease: Insights From the Analysis of Peritoneal Dialysis Patients"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6744-5931","authenticated-orcid":false,"given":"Sho","family":"Sasaki","sequence":"first","affiliation":[{"name":"Center for Innovative Research for Communities and Clinical Excellence (CiRC2LE) Fukushima Medical University  Fukushima Japan"},{"name":"Department of General Medicine, Iwase Satellite for Teaching and Research (STAR) Fukushima Medical University  Fukushima Japan"},{"name":"Section of Clinical Epidemiology, Department of Community Medicine Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0395-9770","authenticated-orcid":false,"given":"Kiichiro","family":"Fujisaki","sequence":"additional","affiliation":[{"name":"Department of Nephrology Iizuka Hospital  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hikaru","family":"Uematsu","sequence":"additional","affiliation":[{"name":"Division of Nephrology Toho University Ohashi Medical Center  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Tojinkai Hospital  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiaki","family":"Nakano","sequence":"additional","affiliation":[{"name":"Department of Medical and Clinical Science, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Abe","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Hypertension and Endocrinology, Department of Medicine Nihon University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0563-3320","authenticated-orcid":false,"given":"Norio","family":"Hanafusa","sequence":"additional","affiliation":[{"name":"Department of Blood Purification Tokyo Women's Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0285-8388","authenticated-orcid":false,"given":"Nobuhiko","family":"Joki","sequence":"additional","affiliation":[{"name":"Division of Nephrology Toho University Ohashi Medical Center  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,7]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002\u20108703(75)90089\u20107"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.08.039"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2024.03.007"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.03.519"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacasi.2024.10.013"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/nep.12808"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000529664"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10157\u2010019\u201001773\u2010y"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882\u2010022\u201002685\u2010y"},{"key":"e_1_2_12_11_1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1744-9987.2011.01050.x","article-title":"Overview of Regular Dialysis Treatment in Japan (As of 31 December 2009): Chronic Dialysis Treatment in Japan 2009","volume":"16","author":"Nakai S.","year":"2012","journal-title":"Therapeutic Apheresis and Dialysis"},{"key":"e_1_2_12_12_1","first-page":"353","article-title":"An Anlysis of the Time\u2010Relations of Electrocardiograms","volume":"7","author":"Bazett H. 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