{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T10:31:23Z","timestamp":1788777083176,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["115\u2010S0141"],"award-info":[{"award-number":["115\u2010S0141"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 112\u20102314\u2010B\u2010002\u2010232\u2010MY3"],"award-info":[{"award-number":["NSTC 112\u20102314\u2010B\u2010002\u2010232\u2010MY3"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Oxidative stress is a key driver of chronic kidney disease and its complications. However, integrative measures capturing the oxidative burden and anti\u2010oxidative defense remain under\u2010explored as prognostic tools. We investigated whether composite oxidative (OxyScore) and anti\u2010oxidative (Anti\u2010OxyScore) indices are associated with mortality in patients undergoing maintenance hemodialysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed a prospectively established multicentric cohort of patients with end\u2010stage kidney disease (ESKD) receiving chronic hemodialysis. Comprehensive clinical, biochemical, and functional data were collected. Composite oxidative and anti\u2010oxidative indices were derived from predefined biomarker panels. Patients were stratified into high and low OxyScore or Anti\u2010OxyScore groups. Cox proportional hazards models were used to evaluate associations between OxyScore, Anti\u2010OxyScore, and all\u2010cause mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Totally 145 patients were included, with comparable baseline characteristics between groups. During follow\u2010up, high Anti\u2010OxyScore was independently associated with increased mortality risk (adjusted hazard ratio [aHR] 1.916, 95% confidence interval [CI] 1.119\u20133.281), whereas OxyScore was not significantly associated with mortality after adjustment (aHR 2.100, 95% CI 0.820\u20135.380).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Anti\u2010oxidative capacity, rather than oxidative burden alone, independently predicts mortality in patients with ESKD. These findings underscore the prognostic relevance of impaired anti\u2010oxidative defense and support the use of composite anti\u2010oxidative indices as clinically meaningful biomarkers in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1744-9987.70187","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T09:59:28Z","timestamp":1783677568000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Anti\u2010Oxidative Capacity, but Not Oxidative Burden, Predicts Mortality Among Patients With End\u2010Stage Kidney Disease"],"prefix":"10.1002","author":[{"given":"Szu\u2010Ying","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine National Taiwan University Hospital Yunlin Branch  Douliu City Yunlin County Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2676-292X","authenticated-orcid":false,"given":"Tzu\u2010Ming","family":"Jao","sequence":"additional","affiliation":[{"name":"Global Innovation Joint\u2010Degree Program, International Joint Degree Master's Program in Agro\u2010Biomedical Science in Food and Health National Taiwan University College of Medicine  Taipei Taiwan"},{"name":"Department of Clinical Laboratory Sciences and Medical Biotechnology National Taiwan University College of Medicine  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2892-7986","authenticated-orcid":false,"given":"Chia\u2010Ter","family":"Chao","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of Medicine  Taipei Taiwan"},{"name":"Graduate Institute of Toxicology National Taiwan University College of Medicine  Taipei Taiwan"},{"name":"Graduate Institute of Medical Education and Bioethics National Taiwan University College of Medicine  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8011-2317","authenticated-orcid":false,"given":"Jenq\u2010Wen","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of Medicine  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,10]]},"reference":[{"issue":"10518","key":"e_1_2_14_2_1","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1016\/S0140-6736(25)01853-7","article-title":"Global, Regional, and National Burden of Chronic Kidney Disease in Adults, 1990\u20102023, and Its Attributable Risk Factors: A Systematic Analysis for the Global Burden of Disease Study 2023","volume":"406","author":"GBD 2023 Chronic Kidney Disease Collaborators","year":"2025","journal-title":"Lancet"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfag040"},{"issue":"18","key":"e_1_2_14_4_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms221810084","article-title":"Chronic Kidney Disease: Strategies to Retard Progression","volume":"22","author":"Yan M. 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