{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T13:32:47Z","timestamp":1793885567363,"version":"4.8.0"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2026,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Accurate prediction of final CD34+ cell yield may reduce donor burden by limiting processed blood volume (PBV) during allogeneic peripheral blood stem cell harvest.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed 86 procedures in 81 healthy donors. Predictions based on preprocedure peripheral blood CD34+ cell concentration and interim collection\u2010product CD34+ cell concentration, measured when PBV reached approximately 50\u2009mL\/kg, were compared. Absolute prediction error was compared within procedures. We also evaluated CD34 percent change (CD34% change), defined as the relative change in product CD34+ cell concentration from interim sampling to the final product, and factors associated with CD34% change \u2264\u2009\u221210%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Interim\u2010CD34\u2010based prediction showed a smaller absolute prediction error than Pre\u2010CD34\u2010based prediction (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.034). Median CD34% change was \u22123.6%, and CD34% change \u2264\u2009\u221210% occurred in 27.9% of procedures. Higher preprocedure platelet count was associated with this decrease.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Interim\u2010CD34\u2010based prediction improved yield estimation and may enable PBV optimization during apheresis while maintaining target doses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1744-9987.70189","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:22:34Z","timestamp":1783642954000},"page":"960-970","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Intraprocedural Yield Estimation Using Interim Product\n                    <scp>CD34<\/scp>\n                    + Concentration Improves the Prediction Accuracy in Allogeneic Peripheral Blood Stem Cell Harvest"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1021-245X","authenticated-orcid":false,"given":"Kazuya","family":"Okada","sequence":"first","affiliation":[{"name":"Transfusion and Hemapheresis Center, Kurashiki Central Hospital  Kurashiki Japan"},{"name":"Department of Hematology\/Oncology Kurashiki Central Hospital  Kurashiki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayumi","family":"Murata","sequence":"additional","affiliation":[{"name":"Transfusion and Hemapheresis Center, Kurashiki Central Hospital  Kurashiki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Yabuta","sequence":"additional","affiliation":[{"name":"Transfusion and Hemapheresis Center, Kurashiki Central Hospital  Kurashiki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryoko","family":"Ishida","sequence":"additional","affiliation":[{"name":"Transfusion and Hemapheresis Center, Kurashiki Central Hospital  Kurashiki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Higuchi","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Kurashiki Central Hospital  Kurashiki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumie","family":"Tasaka","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Kurashiki Central Hospital  Kurashiki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Imanaka","sequence":"additional","affiliation":[{"name":"Transfusion and Hemapheresis Center, Kurashiki Central Hospital  Kurashiki Japan"},{"name":"Department of Hematology\/Oncology Kurashiki Central Hospital  Kurashiki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junko","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Transfusion and Hemapheresis Center, Kurashiki Central Hospital  Kurashiki Japan"},{"name":"Department of Hematology\/Oncology Kurashiki Central Hospital  Kurashiki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryosuke","family":"Takaya","sequence":"additional","affiliation":[{"name":"Transfusion and Hemapheresis Center, Kurashiki Central Hospital  Kurashiki Japan"},{"name":"Department of Hematology\/Oncology Kurashiki Central Hospital  Kurashiki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Nagayama","sequence":"additional","affiliation":[{"name":"Transfusion and Hemapheresis Center, Kurashiki Central Hospital  Kurashiki Japan"},{"name":"Department of Hematology\/Oncology Kurashiki Central Hospital  Kurashiki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3195-2322","authenticated-orcid":false,"given":"Hiroyuki","family":"Muranushi","sequence":"additional","affiliation":[{"name":"Transfusion and Hemapheresis Center, Kurashiki Central Hospital  Kurashiki Japan"},{"name":"Department of Hematology\/Oncology Kurashiki Central Hospital  Kurashiki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Sato","sequence":"additional","affiliation":[{"name":"Transfusion and Hemapheresis Center, Kurashiki Central Hospital  Kurashiki Japan"},{"name":"Department of Hematology\/Oncology Kurashiki Central Hospital  Kurashiki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Maeda","sequence":"additional","affiliation":[{"name":"Transfusion and Hemapheresis Center, Kurashiki Central Hospital  Kurashiki Japan"},{"name":"Department of Hematology\/Oncology Kurashiki Central Hospital  Kurashiki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuhito","family":"Onishi","sequence":"additional","affiliation":[{"name":"Transfusion and Hemapheresis Center, Kurashiki Central Hospital  Kurashiki Japan"},{"name":"Department of Hematology\/Oncology Kurashiki Central Hospital  Kurashiki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4487-5808","authenticated-orcid":false,"given":"Yasunori","family":"Ueda","sequence":"additional","affiliation":[{"name":"Transfusion and Hemapheresis Center, Kurashiki Central Hospital  Kurashiki Japan"},{"name":"Department of Hematology\/Oncology Kurashiki Central Hospital  Kurashiki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,9]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"Japan Marrow Donor Program \u201cUnrelated Peripheral Blood Stem Cell Harvest Manual (Homepage Version) \u201d2025 accessed 19 January 2026 https:\/\/www.jmdp.or.jp\/pdf\/medical\/physicians\/manual\/PBSCH\u2010Manual.pdf."},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.18458"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2024.06.002"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.17990"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16356"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2015.11.016"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3925\/jjtc.69.523"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1703197"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3925\/jjtc.69.634"},{"key":"e_1_2_12_11_1","unstructured":"Japanese Society for Transplantation and Cellular Therapy \u201cGuidelines for Hematopoietic Stem Cell Transplantation: Hematopoietic Stem Cell Harvesting \u201d2024 accessed 20 January 2026 https:\/\/www.jstct.or.jp\/uploads\/files\/guideline\/02_03_harvest03.pdf. [Japanese]."},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.244"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/1744-9987.14202"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000531236"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcyt.2023.09.005"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2005.00701.x"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2019.102679"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.htct.2019.04.004"}],"container-title":["Therapeutic Apheresis and Dialysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1744-9987.70189","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/1744-9987.70189","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1744-9987.70189","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T13:01:37Z","timestamp":1793883697000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/1744-9987.70189"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,9]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["10.1002\/1744-9987.70189"],"URL":"https:\/\/doi.org\/10.1002\/1744-9987.70189","archive":["Portico"],"relation":{},"ISSN":["1744-9979","1744-9987"],"issn-type":[{"value":"1744-9979","type":"print"},{"value":"1744-9987","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,9]]},"assertion":[{"value":"2026-04-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}