{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T11:43:46Z","timestamp":1785843826377,"version":"3.56.0"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Vascular calcification (VC) is prevalent among hemodialysis (HD) patients and represents a key factor contributing to high mortality rates. Therefore, there is a need for biomarkers capable of accurately and efficiently diagnosing VC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To investigate the predictive value of miR\u20103150b\u20103p for VC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Clinically, we recruited 145 HD patients with VC and 120 without VC. Serum levels of miR\u20103150b\u20103p were evaluated by RT\u2010qPCR. The predictive value of miR\u20103150b\u20103p for VC was assessed using ROC curves and logistic regression models. PTH and osteocalcin levels were measured by ELISA. Target gene prediction was performed using bioinformatics methods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Noncalcified and calcified HD patients showed significant differences in age, dialysis duration, ALP, calcium, and CRP. Furthermore, miR\u20103150b\u20103p was upregulated in the calcified group, with higher levels correlating to more severe calcification. Logistic regression analysis indicated that miR\u20103150b\u20103p, age, and CRP were independent risk factors for VC development, with miR\u20103150b\u20103p demonstrating good diagnostic performance for VC. Crucially, miR\u20103150b\u20103p positively correlated with PTH and osteocalcin levels. Bioinformatics analysis revealed that its target genes were extensively involved in processes such as transcriptional regulation, nervous system development, and cell differentiation. Furthermore, these target genes may participate in pathways including cancer, axon guidance, and thyroid hormone signaling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Overexpressed miR\u20103150b\u20103p participated in the VC process of HD patients. Furthermore, it exhibited potential predictive value for VC. Our study provides an alternative diagnostic biomarker for VC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1744-9987.70190","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T10:46:57Z","timestamp":1785840417000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Predictive Value of Serum\n                    <scp>miR<\/scp>\n                    \u20103150b\u20103p for Vascular Calcification in Hemodialysis Patients"],"prefix":"10.1002","author":[{"given":"Ping","family":"Xia","sequence":"first","affiliation":[{"name":"Department of Blood Purification Centre The Second People's Hospital of Hefei, Hefei Hospital Affiliated to Anhui Medical University  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusen","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Nephrology Sinopharm Dongfeng General Hospital, Hubei University of Medicine  Shiyan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4594-3937","authenticated-orcid":false,"given":"Li","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of General Practice Chinese and Western Medicine Hospital of Panzhihua  Panzhihua China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuezhen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Renal Rheumatology and Immunology, Haemodialysis Centre XianJu People's Hospital, Zhejiang Southeast Campus of Zhejiang Provincial People's Hospital, Affiliated Xianju's Hospital, Hangzhou Medical College  Xianju Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,4]]},"reference":[{"issue":"2","key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"50724","DOI":"10.31083\/BJHM50724","article-title":"Analysis of Factors Influencing Subjective Well\u2010Being in Young and Middle\u2010Aged Patients Undergoing Maintenance Hemodialysis","volume":"87","author":"Yang M.","year":"2026","journal-title":"British Journal of Hospital Medicine"},{"issue":"6","key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1097\/MBC.0000000000001357","article-title":"Predictive Value of miR\u201024\u20103p and miR\u20101277\u20105p in Hemodialysis Patients With Vascular Access Thrombosis","volume":"36","author":"Jalakani R.","year":"2025","journal-title":"Blood Coagulation and Fibrinolysis"},{"issue":"3","key":"e_1_2_11_4_1","doi-asserted-by":"crossref","first-page":"e70474","DOI":"10.1002\/nop2.70474","article-title":"Anxiety, Social Support and Coping Strategies in Patients Undergoing Maintenance Haemodialysis","volume":"13","author":"Aslan H.","year":"2026","journal-title":"Nursing Open"},{"issue":"12","key":"e_1_2_11_5_1","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.3390\/medicina61122169","article-title":"Vascular Calcification in Chronic Kidney Disease and Hemodialysis: Pathophysiological Mechanisms and Emerging Biomarkers","volume":"61","author":"Palamar M.","year":"2025","journal-title":"Medicina"},{"issue":"1","key":"e_1_2_11_6_1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1620\/tjem.2025.J064","article-title":"Effect of Serum miR\u2010106a\u20105p on Vascular Calcification in Dialysis Patients","volume":"268","author":"Zhang H.","year":"2026","journal-title":"Tohoku Journal of Experimental Medicine"},{"issue":"1","key":"e_1_2_11_7_1","doi-asserted-by":"crossref","first-page":"118","DOI":"10.55519\/JAMC-01-9399","article-title":"Comparison of Vascular Calcification and Mineral Bone Disease in Non\u2010Dialysis (CKD4\/5ND) vs Dialysis Dependent (CKD5D) Patients","volume":"34","author":"Azam M. 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T.","year":"2019","journal-title":"Journal of International Medical Research"},{"issue":"3","key":"e_1_2_11_11_1","doi-asserted-by":"crossref","first-page":"sfae038","DOI":"10.1093\/ckj\/sfae038","article-title":"Circulating miR\u2010129\u20103p in Combination With Clinical Factors Predicts Vascular Calcification in Hemodialysis Patients","volume":"17","author":"Jin J.","year":"2024","journal-title":"Clinical Kidney Journal"},{"issue":"1","key":"e_1_2_11_12_1","doi-asserted-by":"crossref","first-page":"2313175","DOI":"10.1080\/0886022X.2024.2313175","article-title":"Construction of a miR\u201015a\u2010Based Risk Prediction Model for Vascular Calcification Detection in Patients Undergoing Hemodialysis","volume":"46","author":"Fu C.","year":"2024","journal-title":"Renal Failure"},{"key":"e_1_2_11_13_1","doi-asserted-by":"crossref","first-page":"311076029625139","DOI":"10.1177\/10760296251399647","article-title":"miR\u20103150b\u20103p Promotes Vascular Smooth Muscle Cell Injury by Targeting ARL5B","volume":"31","author":"Wang W.","year":"2025","journal-title":"Clinical and Applied Thrombosis\/Hemostasis"},{"key":"e_1_2_11_14_1","doi-asserted-by":"crossref","first-page":"2999","DOI":"10.2147\/IJGM.S418913","article-title":"Uncovering Candidate mRNAs, Signaling Pathways and Immune Cells in Atherosclerotic Plaque and Ischemic Stroke","volume":"16","author":"Zhang X.","year":"2023","journal-title":"International Journal of General Medicine"},{"key":"e_1_2_11_15_1","doi-asserted-by":"crossref","first-page":"521","DOI":"10.5551\/jat.RV22048","article-title":"Two\u2010Step Clinical Pathways to Cardiovascular Mortality in Chronic Kidney Disease and Dialysis\u2014A Narrative Review","volume":"33","author":"Shoji T.","year":"2026","journal-title":"Journal of Atherosclerosis and Thrombosis"},{"key":"e_1_2_11_16_1","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.16068","article-title":"Analysis of Influencing Factors of Anxiety and Depression in Maintenance Hemodialysis Patients and Its Correlation With BDNF, NT\u20103 and 5\u2010HT Levels","volume":"11","author":"Peng X.","year":"2023","journal-title":"PeerJ"},{"issue":"9","key":"e_1_2_11_17_1","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.12669\/pjms.40.9.9076","article-title":"Effect of Periodic Nursing Interventions on Improving Compliance Behavior and Health Status in Long\u2010Term Hemodialysis Patients","volume":"40","author":"Wang Y.","year":"2024","journal-title":"Pakistan Journal of Medical Sciences"},{"key":"e_1_2_11_18_1","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1111\/hdi.70060","article-title":"Effect of Progressive Muscle Relaxation Exercises on Hemodialysis\u2010Related Symptoms and Quality of Life: A Randomized Controlled Trial","volume":"30","author":"To\u011fluk S.","year":"2026","journal-title":"Hemodialysis International"},{"issue":"2","key":"e_1_2_11_19_1","doi-asserted-by":"crossref","first-page":"e71696","DOI":"10.1002\/hsr2.71696","article-title":"The Impact of a Collaborative Learning Intervention on Nurses' Knowledge and Practice in Hemodialysis Vascular Access Care: A Randomized Controlled Trial","volume":"9","author":"Negin A.","year":"2026","journal-title":"Health Science Reports"},{"issue":"3","key":"e_1_2_11_20_1","first-page":"e322099","article-title":"Considerations in the Use of Mouse Models of Vascular and Valvular Calcification","volume":"46","author":"Hsu J. J.","year":"2026","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"issue":"1","key":"e_1_2_11_21_1","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1159\/000548408","article-title":"Calcium\u2010Phosphorus Metabolism in Chronic Kidney Disease and Its Relationship With Vascular Calcification","volume":"50","author":"Ran L.","year":"2025","journal-title":"Kidney and Blood Pressure Research"},{"issue":"23","key":"e_1_2_11_22_1","doi-asserted-by":"crossref","first-page":"13096","DOI":"10.3390\/ijms252313096","article-title":"Understanding Vascular Calcification in Chronic Kidney Disease: Pathogenesis and Therapeutic Implications","volume":"25","author":"Siracusa C.","year":"2024","journal-title":"International Journal of Molecular Sciences"},{"issue":"10","key":"e_1_2_11_23_1","doi-asserted-by":"crossref","first-page":"3307","DOI":"10.1007\/s11255-025-04535-w","article-title":"Risk Factors for Coronary Artery Calcification in Chinese Patients Undergoing Maintenance Hemodialysis: A Meta\u2010Analysis","volume":"57","author":"Li M.","year":"2025","journal-title":"International Urology and Nephrology"},{"issue":"2","key":"e_1_2_11_24_1","doi-asserted-by":"crossref","first-page":"2368091","DOI":"10.1080\/0886022X.2024.2368091","article-title":"Association of Plasma microRNA\u201016\u20105p and Abdominal Aortic Calcification in Maintenance Hemodialysis Patients","volume":"46","author":"Liang Q.","year":"2024","journal-title":"Renal Failure"},{"key":"e_1_2_11_25_1","doi-asserted-by":"crossref","DOI":"10.23876\/j.krcp.24.149","article-title":"Efficacy of Ophthalmic Examinations for Predicting Vascular Calcification in Patients Undergoing Maintenance Hemodialysis","author":"Park W. 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