{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T01:02:39Z","timestamp":1784682159997,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study aimed to investigate the clinical background associated with extracorporeal circuit coagulation (ECC) with a specific focus on the impact of orthopedic surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A single\u2010center retrospective observational study of 290 hospitalized adult hemodialysis patients (men\/women: 204\/86, median age: 70\u2009years) was included. Univariate and multivariate negative binomial regression analyses were performed to identify factors associated with ECC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010five ECC events were observed in a total of 20 (6.8%) patients (men\/women: 14\/6). In univariate negative binomial regression analysis, orthopedic surgery was significantly associated with ECC (incidence rate ratio, 4.16; 95% confidence interval, 1.68\u201310.0,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). In multivariate analysis, the performance of orthopedic surgery emerged as a potent and independent factor for an increased frequency of ECC.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Orthopedic surgery is significantly associated with an increased frequency of ECC. This finding highlights the importance of considering orthopedic surgery as a potential clinical factor for ECC in perioperative hemodialysis management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1744-9987.70195","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:25:27Z","timestamp":1784679927000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Orthopedic Surgery as a Risk Factor for Extracorporeal Circuit Coagulation in Patients on Hemodialysis: A Retrospective Observational Study"],"prefix":"10.1002","author":[{"given":"Yuki","family":"Nakamura","sequence":"first","affiliation":[{"name":"Division of Clinical Engineering Sapporo Medical University Hospital  Sapporo 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Cardiovascular\u2010Kidney\u2010Metabolic Medicine, Department of Internal Medicine Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun","family":"Tsugawa","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Endocrinology National Defense Medical College  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Enami","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular\u2010Kidney\u2010Metabolic Medicine, Department of Internal Medicine Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Terasawa","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular\u2010Kidney\u2010Metabolic Medicine, Department of Internal Medicine Sapporo Medical University School of Medicine  Sapporo 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