{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:30:31Z","timestamp":1787027431400,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Circuit clotting during polymyxin B hemoperfusion (\n                      <jats:styled-content style=\"fixed-case\">PMX<\/jats:styled-content>\n                      \u2010\n                      <jats:styled-content style=\"fixed-case\">HP<\/jats:styled-content>\n                      ) therapy could be associated with poor clinical outcomes in patients with septic shock.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This post hoc sub\u2010analysis of the\n                      <jats:styled-content style=\"fixed-case\">BEAT<\/jats:styled-content>\n                      \u2010\n                      <jats:styled-content style=\"fixed-case\">SHOCK<\/jats:styled-content>\n                      registry included 82 of 309 adults with septic shock requiring high\u2010dose norepinephrine (\u2265\u20090.2\u2009\u03bcg\/kg\/min) that underwent\n                      <jats:styled-content style=\"fixed-case\">PMX<\/jats:styled-content>\n                      \u2010\n                      <jats:styled-content style=\"fixed-case\">HP<\/jats:styled-content>\n                      therapy. We compared 28\u2010day mortality between patients with and without circuit clotting during the first session.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 82 patients (median\n                      <jats:styled-content style=\"fixed-case\">PMX<\/jats:styled-content>\n                      \u2010\n                      <jats:styled-content style=\"fixed-case\">HP<\/jats:styled-content>\n                      duration, 1016\u2009min), 25 patients (30%) had premature termination due to circuit clotting of those patients, 28\u2010day mortality was 16% (4\/25), as compared with 18% (10\/57) in those without circuit clotting (adjusted hazard ratio 0.58; 95% confidence interval 0.13\u20132.55). Lower serum albumin was associated with circuit clotting (adjusted hazard ratio 0.48; 95% confidence interval 0.27\u20130.85; per 1\u2009g\/\n                      <jats:styled-content style=\"fixed-case\">dL<\/jats:styled-content>\n                      increase).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Circuit clotting occurred in one\u2010third of patients but was not associated with poorer outcomes.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      <jats:styled-content style=\"fixed-case\">UMIN<\/jats:styled-content>\n                      Clinical Trial Registry, registration no.\n                      <jats:styled-content style=\"fixed-case\">UMIN000038302<\/jats:styled-content>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1744-9987.70210","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:01:13Z","timestamp":1787025673000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Incidence and Clinical Outcomes of Circuit Clotting During Prolonged Polymyxin B Hemoperfusion in Patients With Septic Shock: A Post Hoc Analysis of a Prospective Cohort Study"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5473-2731","authenticated-orcid":false,"given":"Kyohei","family":"Miyamoto","sequence":"first","affiliation":[{"name":"Department of Emergency and Critical Care Medicine Wakayama Medical University  Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4471-4788","authenticated-orcid":false,"given":"Yu","family":"Kawazoe","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine National Hospital Organization Sendai Medical Center  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6844-739X","authenticated-orcid":false,"given":"Takeshi","family":"Morimoto","sequence":"additional","affiliation":[{"name":"Department of Data Science Hyogo Medical University  Nishinomiya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Yamamura","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine Osaka Minato Central Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Miyagawa","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine Sendai City Hospital  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinori","family":"Ohta","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine National Hospital Organization Kyoto Medical Center  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2528-1913","authenticated-orcid":false,"given":"Mami","family":"Shibata","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine Wakayama Medical University  Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9670-754X","authenticated-orcid":false,"given":"Nozomu","family":"Shima","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine Wakayama Medical University  Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2716-8861","authenticated-orcid":false,"given":"Tsuyoshi","family":"Nakashima","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine Wakayama Medical University  Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeaki","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine Wakayama Medical University  Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0287"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0289"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744\u20109987.1998.tb00066.x"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.856"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.14618"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134\u2010018\u20105463\u20107"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2213\u20102600(26)00047\u20100"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13613\u2010016\u20100178\u20109"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134\u2010015\u20103751\u2010z"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.shk.0000159930.87737.8a"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000491744"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40560\u2010017\u20100214\u20103"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2014.03.031"},{"key":"e_1_2_12_15_1","unstructured":"Japan Ministry of Health Labour and Welfare \u201cEthical Guidelines for Medical and Biological Research Involving Human Subjects \u201daccessed August 13 2024 https:\/\/www.mhlw.go.jp\/content\/001077424.pdf."},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/cce.0000000000001320"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.14865"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2018.12.019"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40560\u2010019\u20100383\u20103"},{"key":"e_1_2_12_20_1","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1097\/00003246-198510000-00009","article-title":"APACHE II: A Severity of Disease Classification System","volume":"13","author":"Knaus W. A.","year":"1985","journal-title":"Critical Care Medicine"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwq433"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882\u2010017\u20100445\u20105"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.70025"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476\u20105381.1992.tb14465.x"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.3109\/09537109509078476"}],"container-title":["Therapeutic Apheresis and Dialysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1744-9987.70210","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/1744-9987.70210","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1744-9987.70210","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:01:16Z","timestamp":1787025676000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/1744-9987.70210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,17]]},"references-count":24,"alternative-id":["10.1002\/1744-9987.70210"],"URL":"https:\/\/doi.org\/10.1002\/1744-9987.70210","archive":["Portico"],"relation":{},"ISSN":["1744-9979","1744-9987"],"issn-type":[{"value":"1744-9979","type":"print"},{"value":"1744-9987","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,17]]},"assertion":[{"value":"2026-04-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"1744-9987.70210"}}