{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T06:24:19Z","timestamp":1787207059630,"version":"build-2736575974"},"reference-count":13,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Guillain\u2013Barr\u00e9 syndrome (GBS) is an acute immune\u2010mediated peripheral neuropathy for which therapeutic apheresis is an established treatment option. Various treatment modalities, including double filtration plasmapheresis (DFPP), are widely used in clinical practice; however, real\u2010world data on their clinical outcomes and adjunctive treatment strategies remain limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed 43 patients with GBS treated at a single tertiary center between June 2018 and October 2024, including 36 patients who received DFPP\u2010containing regimens and 7 who received IVIG alone. Short\u2010term functional outcomes were assessed using the modified Rankin scale (mRS) and Hughes functional grading scale (HFGS) at hospital admission before treatment and after completion of inpatient treatment. Changes in immunoglobulin and complement levels were evaluated in patients receiving DFPP. Exploratory analyses compared functional score changes across different treatment regimens.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At hospital discharge, mRS and HFGS scores were significantly lower than baseline in patients receiving DFPP alone, DFPP combined with intravenous methylprednisolone, or IVIG alone. No significant differences in changes in functional scores were observed between the DFPP\u2010alone and IVIG\u2010alone groups or between the DFPP\u2010alone and DFPP\u2010plus\u2010corticosteroid groups. DFPP significantly reduced serum immunoglobulin and complement levels; however, the percentage reductions in IgG, IgA, and IgM were not significantly correlated with short\u2010term changes in mRS or HFGS scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this real\u2010world cohort, DFPP\u2010containing treatment was associated with short\u2010term improvement in functional scores from hospital admission to hospital discharge. No statistically significant difference in short\u2010term functional improvement was detected between the DFPP\u2010alone and DFPP\u2010plus\u2010IVMP groups. However, the small sample size, heterogeneous treatment regimens, and lack of long\u2010term follow\u2010up preclude conclusions regarding sustained or comparative efficacy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1744-9987.70211","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T05:35:46Z","timestamp":1787204146000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Outcomes of Double Filtration Plasmapheresis in Guillain\u2013Barr\u00e9 Syndrome: A Single\u2010Center Retrospective Study"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8835-3688","authenticated-orcid":false,"given":"Jingwen","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurology, Renji Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Renji Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Renji Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufang","family":"Mei","sequence":"additional","affiliation":[{"name":"Department of Neurology, Renji Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Neurology, Renji Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiying","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Renji Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Neurology, Renji Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Renji Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2502-0177","authenticated-orcid":false,"given":"Wenbin","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Renji Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,19]]},"reference":[{"issue":"12","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"3646","DOI":"10.1111\/ene.16073","article-title":"European Academy of Neurology\/Peripheral Nerve Society Guideline on Diagnosis and Treatment of Guillain\u2013Barr\u00e9 Syndrome","volume":"30","author":"Doorn P. A.","year":"2023","journal-title":"European Journal of Neurology"},{"issue":"3","key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1007\/s12028-023-01707-3","article-title":"Guidelines for Neuroprognostication in Adults With Guillain\u2013Barr\u00e9 Syndrome","volume":"38","author":"Busl K. M.","year":"2023","journal-title":"Neurocritical Care"},{"issue":"2","key":"e_1_2_10_4_1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/1744-9987.13548","article-title":"Double Filtration Plasmapheresis: Review of Current Clinical Applications","volume":"25","author":"Hirano R.","year":"2021","journal-title":"Therapeutic Apheresis and Dialysis"},{"issue":"1","key":"e_1_2_10_5_1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/1744-9987.13906","article-title":"Real\u2010World Application of Plasmapheresis for Neurological Disease: Results From the Japan\u2010Plasmapheresis Outcome and Practice Patterns Study","volume":"27","author":"Lin Y.","year":"2023","journal-title":"Therapeutic Apheresis and Dialysis"},{"issue":"9","key":"e_1_2_10_6_1","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1177\/09612033231187229","article-title":"Clinical Efficacy of Centrifugal\u2010Membranous Hybrid Double Filtration Plasmapheresis and Membranous Double Filtration Plasmapheresis on Severe Lupus Nephritis","volume":"32","author":"Dong J.","year":"2023","journal-title":"Lupus"},{"issue":"1","key":"e_1_2_10_7_1","doi-asserted-by":"crossref","DOI":"10.1186\/s12883-022-02567-8","article-title":"Comparison of the Effects of Different Doses of Glucocorticoids on Distinct Subtypes of Guillain\u2013Barre Syndrome in Southern China","volume":"22","author":"Ma L.","year":"2022","journal-title":"BMC Neurology"},{"issue":"10280","key":"e_1_2_10_8_1","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1016\/S0140-6736(21)00517-1","article-title":"Guillain\u2013Barr\u00e9 Syndrome","volume":"397","author":"Shahrizaila N.","year":"2021","journal-title":"Lancet"},{"key":"e_1_2_10_9_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneuroim.2024.578463","article-title":"Effectiveness of Double\u2010Filtration Plasmapheresis in Reducing Immunoglobulin and Culprit Antibody Levels in Neuroimmune Disorders: A Single\u2010Center Retrospective Analysis From China","volume":"396","author":"Lin Y.","year":"2024","journal-title":"Journal of Neuroimmunology"},{"issue":"3","key":"e_1_2_10_10_1","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1002\/(SICI)1098-1101(1999)14:3<126::AID-JCA4>3.0.CO;2-W","article-title":"Experience of Double Filtration Plasmapheresis in the Treatment of Guillain\u2013Barr\u00e9 Syndrome","volume":"14","author":"Chen W. H.","year":"1999","journal-title":"Journal of Clinical Apheresis"},{"issue":"41","key":"e_1_2_10_11_1","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000027351","article-title":"Efficacy of Therapies in the Treatment of Guillain\u2013Barr\u00e9 Syndrome: A Network Meta\u2010Analysis","volume":"100","author":"Lin J.","year":"2021","journal-title":"Medicine (Baltimore)"},{"issue":"1","key":"e_1_2_10_12_1","doi-asserted-by":"crossref","first-page":"120","DOI":"10.4103\/aian.AIAN_378_19","article-title":"A Comparative Study of IVIG Versus IVIG With IV Methylprednisolone in Guillain\u2013Barr\u00e9 Syndrome","volume":"23","author":"Bhattiprolu R. K.","year":"2020","journal-title":"Annals of Indian Academy of Neurology"},{"issue":"9404","key":"e_1_2_10_13_1","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/S0140-6736(03)15324-X","article-title":"Effect of Methylprednisolone When Added to Standard Treatment With Intravenous Immunoglobulin for Guillain\u2013Barr\u00e9 Syndrome: Randomised Trial","volume":"363","author":"Koningsveld R.","year":"2004","journal-title":"Lancet"},{"issue":"1","key":"e_1_2_10_14_1","doi-asserted-by":"crossref","first-page":"8354","DOI":"10.1038\/s41598-023-35610-w","article-title":"Extensive Cytokine Biomarker Analysis in Serum of Guillain\u2013Barr\u00e9 Syndrome Patients","volume":"13","author":"Li X.","year":"2023","journal-title":"Scientific Reports"}],"container-title":["Therapeutic Apheresis and Dialysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1744-9987.70211","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/1744-9987.70211","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1744-9987.70211","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T05:35:48Z","timestamp":1787204148000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/1744-9987.70211"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,19]]},"references-count":13,"alternative-id":["10.1002\/1744-9987.70211"],"URL":"https:\/\/doi.org\/10.1002\/1744-9987.70211","archive":["Portico"],"relation":{},"ISSN":["1744-9979","1744-9987"],"issn-type":[{"value":"1744-9979","type":"print"},{"value":"1744-9987","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,19]]},"assertion":[{"value":"2026-01-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"1744-9987.70211"}}