{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T02:18:49Z","timestamp":1787624329137,"version":"build-2736575974"},"reference-count":18,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Elevated lipoprotein(a) (Lp(a)) is a recognized independent cardiovascular risk factor, particularly in patients with chronic kidney disease (CKD) undergoing hemodialysis, for whom pharmacological treatment options remain limited. Lipoprotein apheresis with double\u2010filtration plasmapheresis (DFPP) is a semiselective apheresis technique associated with reductions in serum Lp(a) levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To describe the clinical and biological outcomes of lipoprotein apheresis with DFPP in five hemodialysis patients with markedly elevated Lp(a) levels (&gt;\u2009200\u2009nmol\/L) and a history of cardiovascular disease (CVD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We report a case series of five CKD patients undergoing hemodialysis who underwent lipoprotein apheresis with DFPP, either concomitantly with hemodialysis or separately depending on hemodynamic tolerance. Biological parameters, including Lp(a), low\u2010density lipoprotein (LDL) cholesterol, triglycerides, fibrinogen, blood pressure, and session characteristics (plasma volume treated and session duration), were assessed before and after lipoprotein apheresis sessions with DFPP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All patients experienced marked reductions in Lp(a), LDL cholesterol, triglycerides, and fibrinogen following lipoprotein apheresis sessions. The procedure was performed concomitantly with hemodialysis in four patients with stable hemodynamic parameters. In one patient, the procedure was carried out separately from hemodialysis because of hemodynamic intolerance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Lipoprotein apheresis with DFPP appeared effective in reducing elevated Lp(a) levels and was generally well tolerated in hemodialysis patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1744-9987.70213","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T01:59:21Z","timestamp":1787363961000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Series: Management of Elevated Lipoprotein(a) by Double\u2010Filtration Plasmapheresis in Hemodialysis Patients With Chronic Kidney Disease"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-6746-6790","authenticated-orcid":false,"given":"Zead","family":"Tubail","sequence":"first","affiliation":[{"name":"Department of Nephrology, Hemodialysis and Therapeutic Apheresis Metz\u2010Thionville Regional Hospital Center, Mercy Hospital  Metz France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8381-2607","authenticated-orcid":false,"given":"Christophe","family":"Goetz","sequence":"additional","affiliation":[{"name":"Clinical Research Support Unit Metz\u2010Thionville Regional Hospital Center, Mercy Hospital  Metz France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Savenkoff","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Hemodialysis and Therapeutic Apheresis Metz\u2010Thionville Regional Hospital Center, Mercy Hospital  Metz France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9520-8747","authenticated-orcid":false,"given":"Nadia","family":"Ouamara","sequence":"additional","affiliation":[{"name":"Department of Clinical Research H\u00f4pital Robert Schuman, Non\u2010Profit Private Hospitals of Metz, Groupe UNEOS  Metz France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,21]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.11.042"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq386"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00041433\u2010200308000\u201000004"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2004110922"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V111105"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R056549"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac361"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.037184"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.002432"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.12135"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.116.307983"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.70020"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021\u20109150(00)00371\u20103"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2024.04.134"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.htct.2021.01.009"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11789\u2010017\u20100089\u20109"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfae032"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2019.09.010"}],"container-title":["Therapeutic Apheresis and 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