{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T23:03:35Z","timestamp":1789340615177,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T00:00:00Z","timestamp":1789257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T00:00:00Z","timestamp":1789257600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Longitudinal changes in left ventricular ejection fraction (LVEF) after commencing hemodialysis and their prognostic implications remain poorly characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We studied 278 patients who started hemodialysis between 2010 and 2022, underwent echocardiography within 90\u2009days, and had at least one follow\u2010up study. LVEF trajectories were analyzed using linear mixed\u2010effects models and locally weighted scatterplot smoothing. Mortality was assessed using baseline, 1\u2010year landmark, and time\u2010updated LVEF categories.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>LVEF initially improved but then declined in the 32 patients with a baseline LVEF \u2264\u200940%, whereas it remained stable in those with a baseline LVEF &gt;\u200940%. Baseline LVEF \u2264\u200940% was associated with higher mortality (adjusted HR: 2.97, 95% CI: 1.38\u20136.37), with mortality risk increasing if LVEF remained \u2264\u200940% at 1\u2009year. Time\u2010updated LVEF \u2264\u200940% was independently associated with mortality (adjusted HR: 4.41, 95% CI: 2.37\u20138.22).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>LVEF changes dynamically after initiation of hemodialysis, and serial assessments identify patients at higher risk of mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1744-9987.70220","type":"journal-article","created":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T22:29:56Z","timestamp":1789338596000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Temporal Changes in Left Ventricular Ejection Fraction After Initiating Hemodialysis"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-9635-6975","authenticated-orcid":false,"given":"Asahi","family":"Oshima","sequence":"first","affiliation":[{"name":"Division of Cardiology Mitsui Memorial Hospital  Tokyo Japan"},{"name":"CORRIB Research Centre for Advanced Imaging and Core Laboratory University of Galway  Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Horiuchi","sequence":"additional","affiliation":[{"name":"Division of Cardiology Mitsui Memorial Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8104-2979","authenticated-orcid":false,"given":"Takuya","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Division of Cardiology Mitsui Memorial Hospital  Tokyo Japan"},{"name":"Department of Cardiovascular Medicine The University of Tokyo Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8816-9197","authenticated-orcid":false,"given":"Kazushige","family":"Ito","sequence":"additional","affiliation":[{"name":"Division of Cardiology Mitsui Memorial Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8911-0278","authenticated-orcid":false,"given":"Scot","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Cardiology Royal Blackburn Hospital  Blackburn UK"},{"name":"School of Medicine University of Lancashire  Preston UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7702-0649","authenticated-orcid":false,"given":"Yoshinobu","family":"Onuma","sequence":"additional","affiliation":[{"name":"CORRIB Research Centre for Advanced Imaging and Core Laboratory University of Galway  Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9636-1104","authenticated-orcid":false,"given":"Patrick W.","family":"Serruys","sequence":"additional","affiliation":[{"name":"CORRIB Research Centre for Advanced Imaging and Core Laboratory University of Galway  Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1312-5489","authenticated-orcid":false,"given":"Kengo","family":"Tanabe","sequence":"additional","affiliation":[{"name":"Division of Cardiology Mitsui Memorial Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naobumi","family":"Mise","sequence":"additional","affiliation":[{"name":"Department of Nephrology Mitsui Memorial Hospital  Tokyo 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