{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:52:30Z","timestamp":1791417150986,"version":"4.3.3"},"reference-count":33,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Hyperlipidemia is a major risk factor for atherosclerotic cardiovascular disease (ASCVD). Although statins are the cornerstone of lipid\u2010lowering therapy, their use may be limited in some patients by adverse effects. This study evaluated the possible impact of non\u2010drug treatment using double\u2010filtration plasmapheresis (DFPP) on CD14+ monocytes and to identify alterations in plasma proteomics after DFPP in patients with hyperlipidemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty\u2010seven hyperlipidemic patients were enrolled. Mitochondria changes, lipid peroxidation, reactive oxygen species (ROS), and mitochondrial lipid peroxidation were examined. CD14+ monocyte proteins related to ferroptosis were assayed by western blotting, and plasma proteomic changes were measured by data\u2010independent acquisition (DIA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In comparison to their levels prior to double\u2010filtration plasmapheresis (DFPP), there was a notable reduction in total cholesterol (TC), total triglycerides (TG), low\u2010density lipoprotein cholesterol (LDL\u2010C), lipoprotein(a) (Lp(a)), and small dense low\u2010density lipoprotein cholesterol (sdLDL) after DFPP. DFPP may attenuate ferroptosis in peripheral blood CD14+ monocytes of patients with hyperlipidemia. Three protein candidates were identified from the DIA dataset.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>DFPP exerts lipid\u2010lowering effects in patients with hyperlipidemia. The ACSL4\/LPCAT3\/ALOX5 pathway and the three proteins are likely involved in alleviating ferroptosis.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      identifier: NCT03491956\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1744-9987.70227","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:45:41Z","timestamp":1791416741000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of\n                    <scp>DFPP<\/scp>\n                    on Ferroptosis in Peripheral Blood\n                    <scp>CD14<\/scp>\n                    + Monocytes of Hyperlipidemic Patients Involving the\n                    <scp>ACSL4<\/scp>\n                    \/\n                    <scp>LPCAT3<\/scp>\n                    \/\n                    <scp>ALOX5<\/scp>\n                    Pathway"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3403-7082","authenticated-orcid":false,"given":"Yun","family":"Cheng","sequence":"first","affiliation":[{"name":"Nephrology Department Shanghai Public Health Clinical Center (Fudan University)  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9751-7155","authenticated-orcid":false,"given":"Lan","family":"Li","sequence":"additional","affiliation":[{"name":"Blood Purification Center Shanghai Public Health Clinical Center (Fudan University)  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0740-7637","authenticated-orcid":false,"given":"Qingmei","family":"Yang","sequence":"additional","affiliation":[{"name":"Nephrology Department Shanghai Public Health Clinical Center (Fudan University)  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2751-5763","authenticated-orcid":false,"given":"Meipeng","family":"Wu","sequence":"additional","affiliation":[{"name":"Nephrology Department Shanghai Public Health Clinical Center (Fudan University)  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"issue":"9","key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"e2127573","DOI":"10.1001\/jamanetworkopen.2021.27573","article-title":"Prevalence of Dyslipidemia and Availability of Lipid\u2010Lowering Medications Among Primary Health Care Settings in China","volume":"4","author":"Lu Y.","year":"2021","journal-title":"JAMA Network Open"},{"issue":"4","key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1080\/17474124.2018.1439379","article-title":"The Potential Role of Statins in Treating Liver Disease","volume":"12","author":"Imprialos K. 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