{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:45:28Z","timestamp":1791765928087,"version":"4.3.4"},"reference-count":9,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T00:00:00Z","timestamp":1791676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T00:00:00Z","timestamp":1791676800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Kidney transplant recipients with severe infections often require immunosuppression minimization, increasing the risk of donor\u2010specific antibody (DSA) persistence and antibody\u2010mediated injury. Extracorporeal photopheresis (ECP) may provide immunomodulation while limiting alloimmune activation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed four kidney transplant recipients with severe infectious complications and concomitant DSAs who required immunosuppression reduction. Clinical scenarios included BK viremia, BK virus nephropathy, Epstein\u2013Barr virus\u2010associated post\u2010transplant lymphoproliferative disorder, and recurrent urinary tract infections. ECP was administered for 12\u2009months as adjunctive therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Following ECP initiation, infectious complications improved or resolved in all patients, with reduction of viral replication when present. DSA levels decreased markedly in all cases. Kidney graft function remained stable throughout follow\u2010up, and no episodes of acute rejection were observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>ECP may represent a safe and effective immunomodulatory bridge during immunosuppression minimization in kidney transplant recipients with infections and concomitant DSAs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1744-9987.70231","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:01:57Z","timestamp":1791763317000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Extracorporeal Photopheresis as an Immunomodulatory Bridge in Kidney Transplant Recipients With Infections and Concomitant Donor\u2010Specific Antibodies: A Case Series"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8810-7926","authenticated-orcid":false,"given":"Iacopo","family":"Gianassi","sequence":"first","affiliation":[{"name":"Nephrology, Dialysis and Transplantation Unit Careggi University Hospital  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiammetta","family":"Fossi","sequence":"additional","affiliation":[{"name":"Cellular Therapies and Transfusion Medicine Unit Careggi University Hospital  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0612-3517","authenticated-orcid":false,"given":"Leonardo","family":"Caroti","sequence":"additional","affiliation":[{"name":"Nephrology, Dialysis and Transplantation Unit Careggi University Hospital  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Di Maria","sequence":"additional","affiliation":[{"name":"Nephrology, Dialysis and Transplantation Unit Careggi University Hospital  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aida","family":"Larti","sequence":"additional","affiliation":[{"name":"Nephrology, Dialysis and Transplantation Unit Careggi University Hospital  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9676-7024","authenticated-orcid":false,"given":"Giulia","family":"Antognoli","sequence":"additional","affiliation":[{"name":"Nephrology, Dialysis and Transplantation Unit Careggi University Hospital  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata Angela","family":"Di Pietro","sequence":"additional","affiliation":[{"name":"Nephrology, Dialysis and Transplantation Unit Careggi University Hospital  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Cutruzzul\u00e0","sequence":"additional","affiliation":[{"name":"Nephrology, Dialysis and Transplantation Unit Careggi University Hospital  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Cestone","sequence":"additional","affiliation":[{"name":"Nephrology, Dialysis and Transplantation Unit Careggi University Hospital  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Allegretta","sequence":"additional","affiliation":[{"name":"Nephrology, Dialysis and Transplantation Unit Careggi University Hospital  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9949-3543","authenticated-orcid":false,"given":"Marco","family":"Allinovi","sequence":"additional","affiliation":[{"name":"Nephrology, Dialysis and Transplantation Unit Careggi University Hospital  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lino Calogero","family":"Cirami","sequence":"additional","affiliation":[{"name":"Nephrology, Dialysis and Transplantation Unit Careggi University Hospital  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000003136"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2026.1738675"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm14111106"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.13993"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/ti.2023.11802"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajt.2024.03.019"},{"key":"e_1_2_6_8_1","first-page":"521","article-title":"Extracorporeal Photopheresis in Kidney Transplantation: Proof of Concept, Clinical Outcomes and Perspective","volume":"19","author":"Cr\u00e9pin T.","year":"2023","journal-title":"N\u00e9phrologie and Th\u00e9rapeutique"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/TXD.0000000000001809"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneph.2025.1625060"}],"container-title":["Therapeutic Apheresis and Dialysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1744-9987.70231","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/1744-9987.70231","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1744-9987.70231","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:01:59Z","timestamp":1791763319000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/1744-9987.70231"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,11]]},"references-count":9,"alternative-id":["10.1002\/1744-9987.70231"],"URL":"https:\/\/doi.org\/10.1002\/1744-9987.70231","archive":["Portico"],"relation":{},"ISSN":["1744-9979","1744-9987"],"issn-type":[{"value":"1744-9979","type":"print"},{"value":"1744-9987","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,11]]},"assertion":[{"value":"2026-06-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"1744-9987.70231"}}